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Items: 6

Select item 49546031.

Ribosomal protein S6 kinase 1 signaling regulates mammalian lifespan

Colin Selman, Jennifer M.A. Tullet, Daniela Wieser, Elaine Irvine, Steven J. Lingard, Agharul I. Choudhury, Marc Claret, Hind Al-Qassab, Danielle Carmignac, Faruk Ramadani, Angela Woods, Iain C.A. Robinson, Eugene Schuster, Rachel L. Batterham, Sara C. Kozma, George Thomas, David Carling, Klaus Okkenhaug, Janet M. Thornton, Linda Partridge, David Gems, Dominic J. Withers

Science. Author manuscript; available in PMC 2016 Jul 20.

Published in final edited form as: Science. 2009 Oct 2; 326(5949): 140–144. doi: 10.1126/science.1177221

PMCID:: PMC4954603

Abstract Article PDF–1.1M

Select item 37536902.

Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1

Issam Ben-Sahra, Jessica J. Howell, John M. Asara, Brendan D. Manning

Science. Author manuscript; available in PMC 2013 Sep 15.

Published in final edited form as: Science. 2013 Mar 15; 339(6125): 1323–1328. Published online 2013 Feb 21. doi: 10.1126/science.1228792

PMCID:: PMC3753690

Abstract Article PDF–1.3M

Select item 11710103.

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase.

H Shima, M Pende, Y Chen, S Fumagalli, G Thomas, S C Kozma

EMBO J. 1998 Nov 16; 17(22): 6649–6659. doi: 10.1093/emboj/17.22.6649

PMCID:: PMC1171010

Summary PDF–511K

Select item 3816084.

S6K1^−/−/S6K2^−/− Mice Exhibit Perinatal Lethality and Rapamycin-Sensitive 5′-Terminal Oligopyrimidine mRNA Translation and Reveal a Mitogen-Activated Protein Kinase-Dependent S6 Kinase Pathway

Mario Pende, Sung Hee Um, Virginie Mieulet, Melanie Sticker, Valerie L. Goss, Jurgen Mestan, Matthias Mueller, Stefano Fumagalli, Sara C. Kozma, George Thomas

Mol Cell Biol. 2004 Apr; 24(8): 3112–3124. doi: 10.1128/MCB.24.8.3112-3124.2004