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Select item 111146341.

Structural features underlying the selectivity of the kinase inhibitors NBC and dNBC: role of a nitro group that discriminates between CK2 and DYRK1A

Stefania Sarno, Marco Mazzorana, Ryan Traynor, Maria Ruzzene, Giorgio Cozza, Mario A. Pagano, Flavio Meggio, Giuseppe Zagotto, Roberto Battistutta, Lorenzo A. Pinna

Cell Mol Life Sci. 2012 Feb; 69(3): 449–460. Published online 2011 Jul 1. doi: 10.1007/s00018-011-0758-7

PMCID:: PMC11114634

Abstract Article PDF–555K

Select item 103166772.

The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism

Cecilia Pozzi, Stefania Ferrari, Debora Cortesi, Rosaria Luciani, Robert M. Stroud, Alessia Catalano, Maria Paola Costi, Stefano Mangani

Acta Crystallogr D Biol Crystallogr. 2012 Sep 1; 68(Pt 9): 1232–1241. Published online 2012 Aug 18. doi: 10.1107/S0907444912026236

PMCID:: PMC10316677

Abstract Article PDF–1.6M

Select item 71616263.

Structure of aminopeptidase N from Escherichia coli complexed with the transition‐state analogue aminophosphinic inhibitor PL250

Marie‐Claude Fournié‐Zaluski, Hervé Poras, Bernard P. Roques, Yoshitaka Nakajima, Kiyoshi Ito, Tadashi Yoshimoto

Acta Crystallogr D Biol Crystallogr. 2009 Aug; 65(8): 814–822. Published online 2009 Jul 28. doi: 10.1107/S090744490901779X

PMCID:: PMC7161626

Abstract Article PDF–1.1M

Select item 71161414.

GlcNAcstatin - a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-GlcNAcylation levels

Helge C. Dorfmueller, Vladimir S. Borodkin, Marianne Schimpl, Sharon M. Shepherd, Natalia A. Shpiro, Daan M. F. van Aalten

J Am Chem Soc. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: J Am Chem Soc. 2006 Dec 27; 128(51): 16484–5. doi: 10.1021/ja066743n

PMCID:: PMC7116141

Abstract Article PDF–1.1M

Select item 71142415.

Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease

Lili Zhu, Shyla George, Marco F. Schmidt, Samer I. Al-Gharabli, Jörg Rademann, Rolf Hilgenfeld

Antiviral Res. 2011 Nov; 92(2): 204–212. Published online 2011 Aug 11. doi: 10.1016/j.antiviral.2011.08.001

PMCID:: PMC7114241

Abstract Article PDF–1.3M

Select item 71109926.

A Structural View of the Inactivation of the SARS Coronavirus Main Proteinase by Benzotriazole Esters

Koen H.G. Verschueren, Ksenia Pumpor, Stefan Anemüller, Shuai Chen, Jeroen R. Mesters, Rolf Hilgenfeld

Chem Biol. 2008 Jun 23; 15(6): 597–606. Published online 2008 Jun 20. doi: 10.1016/j.chembiol.2008.04.011

PMCID:: PMC7110992

Abstract Article PDF–972K

Select item 70944537.

Production of Authentic SARS-CoV M^pro with Enhanced Activity: Application as a Novel Tag-cleavage Endopeptidase for Protein Overproduction

Xiaoyu Xue, Haitao Yang, Wei Shen, Qi Zhao, Jun Li, Kailin Yang, Cheng Chen, Yinghua Jin, Mark Bartlam, Zihe Rao

J Mol Biol. 2007 Feb 23; 366(3): 965–975. Published online 2006 Dec 1. doi: 10.1016/j.jmb.2006.11.073

PMCID:: PMC7094453

Abstract Article PDF–1.4M

Select item 70942728.

Structural basis of mercury‐ and zinc‐conjugated complexes as SARS‐CoV 3C‐like protease inhibitors

Cheng-Chung Lee, Chih-Jung Kuo, Min-Feng Hsu, Po-Huang Liang, Jim-Min Fang, Jiun-Jie Shie, Andrew H.-J. Wang

FEBS Lett. 2007 Nov 27; 581(28): 5454–5458. Published online 2007 Nov 5. doi: 10.1016/j.febslet.2007.10.048

PMCID:: PMC7094272

Abstract Article PDF–688K

Select item 70918199.

Natural product juglone targets three key enzymes from Helicobacter pylori: inhibition assay with crystal structure characterization

Yun-hua Kong, Liang Zhang, Zheng-yi Yang, Cong Han, Li-hong Hu, Hua-liang Jiang, Xu Shen

Acta Pharmacol Sin. 2008 Jul; 29(7): 870–876. doi: 10.1111/j.1745-7254.2008.00808.x

PMCID:: PMC7091819

Abstract Article PDF–809K

Select item 708960610.

Structure–Function Analysis of the Short Splicing Variant Carboxypeptidase Encoded by Drosophila melanogaster silver

Sebastián Tanco, Joan L. Arolas, Tibisay Guevara, Julia Lorenzo, Francesc X. Avilés, F. Xavier Gomis-Rüth

J Mol Biol. 2010 Aug 20; 401(3): 465–477. Published online 2010 Jun 25. doi: 10.1016/j.jmb.2010.06.035

PMCID:: PMC7089606

Abstract Article PDF–1.7M

Select item 629046311.

Inhibition of XMRV and HIV-1 proteases by pepstatin A and acetyl-pepstatin

Krisztina Matúz, János Mótyán, Mi Li, Alexander Wlodawer, József Tőzsér

FEBS J. Author manuscript; available in PMC 2018 Dec 12.

Published in final edited form as: FEBS J. 2012 Sep; 279(17): 3276–3286. Published online 2012 Aug 17. doi: 10.1111/j.1742-4658.2012.08714.x

PMCID:: PMC6290463

Abstract Article PDF–1.7M

Select item 518041612.

High-Affinity, Small-Molecule Peptidomimetic Inhibitors of MLL1/WDR5 Protein–Protein Interaction

Hacer Karatas, Elizabeth C. Townsend, Fang Cao, Yong Chen, Denzil Bernard, Liu Liu, Ming Lei, Yali Dou, Shaomeng Wang

J Am Chem Soc. Author manuscript; available in PMC 2016 Dec 23.

Published in final edited form as: J Am Chem Soc. 2013 Jan 16; 135(2): 669–682. Published online 2012 Dec 27. doi: 10.1021/ja306028q

PMCID:: PMC5180416

Abstract Article PDF–1.1M

Select item 497900513.

Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group

Cecilia Bartolucci, Jure Stojan, Qian-sheng Yu, Nigel H. Greig, Doriano Lamba

Biochem J. Author manuscript; available in PMC 2016 Aug 10.

Published in final edited form as: Biochem J. 2012 Jun 1; 444(2): 269–277. doi: 10.1042/BJ20111675

PMCID:: PMC4979005

Abstract Article PDF–583K

Select item 481415714.

Selective Inactivation of a Human Neuronal Silencing Phosphatase by a Small Molecule Inhibitor

Mengmeng Zhang, Eun Jeong Cho, Gayle Burstein, Dionicio Siegel, Yan Zhang

ACS Chem Biol. Author manuscript; available in PMC 2016 Mar 30.

Published in final edited form as: ACS Chem Biol. 2011 May 20; 6(5): 511–519. Published online 2011 Feb 24. doi: 10.1021/cb100357t

PMCID:: PMC4814157

Abstract Article PDF–1.6M

Select item 473950615.

Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach

Megan H. Wright, Barbara Clough, Mark D. Rackham, Kaveri Rangachari, James A. Brannigan, Munira Grainger, David K. Moss, Andrew R. Bottrill, William P. Heal, Malgorzata Broncel, Remigiusz A. Serwa, Declan Brady, David J. Mann, Robin J. Leatherbarrow, Rita Tewari, Anthony J. Wilkinson, Anthony A. Holder, Edward W. Tate

Nat Chem. Author manuscript; available in PMC 2016 Feb 3.

Published in final edited form as: Nat Chem. 2014 Feb; 6(2): 112–121. Published online 2013 Dec 22. doi: 10.1038/nchem.1830

PMCID:: PMC4739506

Abstract Article PDF–2.3M

Select item 448539816.

Studies on an (S)-2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic Acid (AMPA) Receptor Antagonist IKM-159: Asymmetric Synthesis, Neuroactivity, and Structural Characterization

Lina Juknaitė, Yutaro Sugamata, Kazuya Tokiwa, Yuichi Ishikawa, Satoshi Takamizawa, Andrew Eng, Ryuichi Sakai, Darryl S. Pickering, Karla Frydenvang, Geoffrey T. Swanson, Jette S. Kastrup, Masato Oikawa

J Med Chem. Author manuscript; available in PMC 2015 Jun 29.

Published in final edited form as: J Med Chem. 2013 Mar 28; 56(6): 2283–2293. Published online 2013 Mar 13. doi: 10.1021/jm301590z

PMCID:: PMC4485398

Abstract Article PDF–4.1M

Select item 441959017.

Design of Gem-difluoro-bis-Tetrahydrofuran as P2-Ligand for HIV-1 Protease Inhibitors to Improve Brain Penetration: Synthesis, X-ray Studies, and Biological Evaluation

Prof. Arun K. Ghosh, Sofiya Yashchuk, Akira Mizuno, Nilanjana Chakraborty, Johnson Agniswamy, Yuan-Fang Wang, Manabu Aoki, Pedro Miguel Salcedo Gomez, Masayuki Amano, Professor Irene T. Weber, Dr. Hiroaki Mitsuya

ChemMedChem. Author manuscript; available in PMC 2016 Jan 1.

Published in final edited form as: ChemMedChem. 2015 Jan; 10(1): 107–115. Published online 2014 Oct 21. doi: 10.1002/cmdc.201402358

PMCID:: PMC4419590

Abstract Article PDF–1.0M

Select item 436848218.

Human Tyr-tRNA synthetase is a potent PARP-1 activating effector target for resveratrol

Mathew Sajish, Paul Schimmel

Nature. Author manuscript; available in PMC 2015 Sep 19.

Published in final edited form as: Nature. 2015 Mar 19; 519(7543): 370–373. Published online 2014 Dec 22. doi: 10.1038/nature14028

PMCID:: PMC4368482

Abstract Article PDF–3.6M

Select item 433110519.

Structure-Guided, Single-Point Modifications in the Phosphinic Dipeptide Structure Yield Highly Potent and Selective Inhibitors of Neutral Aminopeptidases

Stamatia Vassiliou, Ewelina Węglarz-Tomczak, Łukasz Berlicki, Małgorzata Pawełczak, Bogusław Nocek, Rory Mulligan, Andrzej Joachimiak, Artur Mucha

J Med Chem. 2014 Oct 9; 57(19): 8140–8151. Published online 2014 Sep 5. doi: 10.1021/jm501071f

PMCID:: PMC4331105

Abstract Article PDF–1.9M

Select item 432181620.

Structural and Mechanistic Insights into C-P Bond Hydrolysis by Phosphonoacetate Hydrolase

Vinayak Agarwal, Svetlana A. Borisova, William W. Metcalf, Wilfred A. van der Donk, Satish K. Nair

Chem Biol. Author manuscript; available in PMC 2015 Feb 9.

Published in final edited form as: Chem Biol. 2011 Oct 28; 18(10): 1230–1240. doi: 10.1016/j.chembiol.2011.07.019

PMCID:: PMC4321816

Abstract Article PDF–1.0M

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