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Select item 101179431.

The small molecule inhibitor BX-795 uncouples IL-2 production from inhibition of Th2 inflammation and induces CD4⁺ T cells resembling iTreg

Peter A. Tauber, Bernhard Kratzer, Philipp Schatzlmaier, Ursula Smole, Cordula Köhler, Lisa Rausch, Jan Kranich, Doris Trapin, Alina Neunkirchner, Maja Zabel, Sabrina Jutz, Peter Steinberger, Gabriele Gadermaier, Thomas Brocker, Hannes Stockinger, Sophia Derdak, Winfried F. Pickl

Front Immunol. 2023; 14: 1094694. Published online 2023 Apr 6. doi: 10.3389/fimmu.2023.1094694

PMCID:: PMC10117943

Abstract Article PDF–11M

Select item 100275632.

BX795, a kinase inhibitor, inhibit duck plague virus infection via targeting US3 kinase

Yanming Tian, Bin Tian, Mingshu Wang, Dongjie Cai, Anchun Cheng, Wei Zhang, Ying Wu, Qiao Yang, Xuming Ou, Di Sun, Shaqiu Zhang, Sai Mao, XinXin Zhao, Juan Huang, Qun Gao, Dekang Zhu, Renyong Jia, Shun Chen, Mafeng Liu

Poult Sci. 2023 May; 102(5): 102597. Published online 2023 Feb 16. doi: 10.1016/j.psj.2023.102597

PMCID:: PMC10027563

Abstract Article PDF–2.4M

Select item 85842533.

PDK1 Inhibitor BX795 Improves Cisplatin and Radio-Efficacy in Oral Squamous Cell Carcinoma by Downregulating the PDK1/CD47/Akt-Mediated Glycolysis Signaling Pathway

Shin Pai, Vijesh Kumar Yadav, Kuang-Tai Kuo, Narpati Wesa Pikatan, Chun-Shu Lin, Ming-Hsien Chien, Wei-Hwa Lee, Michael Hsiao, Shao-Chih Chiu, Chi-Tai Yeh, Jo-Ting Tsai

Int J Mol Sci. 2021 Nov; 22(21): 11492. Published online 2021 Oct 25. doi: 10.3390/ijms222111492

PMCID:: PMC8584253

Abstract Article PDF–15M

Select item 84463234.

Prophylactic treatment with BX795 blocks activation of AKT and its downstream targets to protect vaginal keratinocytes and vaginal epithelium from HSV-2 infection

Krishnaraju Madavaraju, Tejabhiram Yadavalli, Sudhanshu Kumar Singh, Farreh Qatanani, Deepak Shukla

Antiviral Res. Author manuscript; available in PMC 2022 Oct 1.

Published in final edited form as: Antiviral Res. 2021 Oct; 194: 105145. Published online 2021 Jul 22. doi: 10.1016/j.antiviral.2021.105145

PMCID:: PMC8446323

Abstract Article PDF–1.9M

Select item 84209085.

TBK1 Inhibitor Exerts Antiproliferative Effect on Glioblastoma Multiforme Cells

Sarah A. Scuderi, Marika Lanza, Giovanna Casili, Francesca Esposito, Cristina Colarossi, Dario Giuffrida, Paterniti Irene, Salvatore Cuzzocrea, Emanuela Esposito, Michela Campolo

Oncol Res. 2021; 28(7-8): 779–790. Published online 2021 Sep 7. doi: 10.3727/096504021X16161478258040

PMCID:: PMC8420908

Abstract Article PDF–817K

Select item 75788636.

Phosphoinositide‐dependent Kinase‐1 (PDPK1) regulates serum/glucocorticoid‐regulated Kinase 3 (SGK3) for prostate cancer cell survival

Geetha Nalairndran, Azad Hassan Abdul Razack, Chun‐Wai Mai, Felicia Fei‐Lei Chung, Kok‐Keong Chan, Ling‐Wei Hii, Wei‐Meng Lim, Ivy Chung, Chee‐Onn Leong

J Cell Mol Med. 2020 Oct; 24(20): 12188–12198. Published online 2020 Sep 14. doi: 10.1111/jcmm.15876

Correction in:: J Cell Mol Med. 2020 Dec; 24(23): 14122–14124.

PMCID:: PMC7578863

Abstract Article PDF–1.1M

Select item 75409107.

An off-target effect of BX795 blocks herpes simplex virus type-1 infection of the eye

Dinesh Jaishankar, Abraam M. Yakoub, Tejabhiram Yadavalli, Alex Agelidis, Neel Thakkar, Satvik Hadigal, Joshua Ames, Deepak Shukla

Sci Transl Med. Author manuscript; available in PMC 2020 Oct 7.

Published in final edited form as: Sci Transl Med. 2018 Feb 14; 10(428): eaan5861. doi: 10.1126/scitranslmed.aan5861

PMCID:: PMC7540910

Abstract Article PDF–1.7M

Select item 75301718.

High-Content Screening of Eukaryotic Kinase Inhibitors Identify CHK2 Inhibitor Activity Against Mycobacterium tuberculosis

Tirosh Shapira, Leah Rankine-Wilson, Joseph D. Chao, Virginia Pichler, Celine Rens, Tom Pfeifer, Yossef Av-Gay

Front Microbiol. 2020; 11: 553962. Published online 2020 Sep 18. doi: 10.3389/fmicb.2020.553962

PMCID:: PMC7530171

Abstract Article PDF–1.7M

Select item 75103279.

Lentiviral delivery of combinatorial CAR/CRISPRi circuit into human primary T cells is enhanced by TBK1/IKKɛ complex inhibitor BX795

Lingyu Li, Yuan Gao, Richa Srivastava, Wei Wang, Qinghui Xiong, Zhiming Fang, Alejandra Pelayo, Carolyn Denson, Angshumala Goswami, Rona Harari-Steinfeld, Zhifen Yang, Lihong Weng, Lei Stanley Qi, Francesco M. Marincola

J Transl Med. 2020; 18: 363. Published online 2020 Sep 23. doi: 10.1186/s12967-020-02526-2

PMCID:: PMC7510327

Abstract Article PDF–1.5M

Select item 744916910.

In Vitro and In Vivo Activity, Tolerability, and Mechanism of Action of BX795 as an Antiviral against Herpes Simplex Virus 2 Genital Infection

James Hopkins, Tejabhiram Yadavalli, Rahul Suryawanshi, Farreh Qatanani, Ipsita Volety, Ram Koganti, Aqsa Iqbal, Deepak Shukla

Antimicrob Agents Chemother. 2020 Sep; 64(9): e00245-20. Prepublished online 2020 Jun 29. Published online 2020 Aug 20. doi: 10.1128/AAC.00245-20

PMCID:: PMC7449169

Abstract Article PDF–1.7M

Select item 738721511.

BX795 Demonstrates Potent Antiviral Benefits against Herpes Simplex Virus-1 Infection of Human Cell Lines

Aqsa Iqbal, Rahul Suryawanshi, Tejabhiram Yadavalli, Ipsita Volety, Deepak Shukla

Antiviral Res. Author manuscript; available in PMC 2021 Aug 1.

Published in final edited form as: Antiviral Res. 2020 Aug; 180: 104814. Published online 2020 May 5. doi: 10.1016/j.antiviral.2020.104814

Correction in:: Antiviral Res. 2022 Apr; 200: 105293.

PMCID:: PMC7387215

Abstract Article PDF–1.8M

Select item 726897812.

Prior inhibition of AKT phosphorylation by BX795 can define a safer strategy to prevent herpes simplex virus-1 infection of the eye

Tejabhiram Yadavalli, Rahul Suryawanshi, Marwan Ali, Aqsa Iqbal, Raghuram Koganti, Joshua Ames, Vinay Kumar Aakalu, Deepak Shukla

Ocul Surf. Author manuscript; available in PMC 2020 Jun 3.

Published in final edited form as: Ocul Surf. 2020 Apr; 18(2): 221–230. Published online 2019 Nov 23. doi: 10.1016/j.jtos.2019.11.011

PMCID:: PMC7268978

Abstract Article PDF–1.7M

Select item 716065713.

The IUPHAR Guide to Immunopharmacology: connecting immunology and pharmacology

Simon D. Harding, Elena Faccenda, Christopher Southan, Adam J. Pawson, Pasquale Maffia, Stephen P. H. Alexander, Anthony P. Davenport, Doriano Fabbro, Francesca Levi‐Schaffer, Michael Spedding, Jamie A. Davies

Immunology. 2020 May; 160(1): 10–23. Published online 2020 Mar 2. doi: 10.1111/imm.13175

PMCID:: PMC7160657

Abstract Article PDF–4.1M

Select item 710311414.

The cardenolide ouabain suppresses coronaviral replication via augmenting a Na⁺/K⁺-ATPase-dependent PI3K_PDK1 axis signaling

Cheng-Wei Yang, Hsin-Yu Chang, Yue-Zhi Lee, Hsing-Yu Hsu, Shiow-Ju Lee

Toxicol Appl Pharmacol. 2018 Oct 1; 356: 90–97. Published online 2018 Jul 25. doi: 10.1016/j.taap.2018.07.028

PMCID:: PMC7103114

Abstract Article PDF–1.3M

Select item 657615915.

Expression of endogenous retroviruses reflects increased usage of atypical enhancers in T cells

Saliha Azébi, Eric Batsché, Frédérique Michel, Etienne Kornobis, Christian Muchardt

EMBO J. 2019 Jun 17; 38(12): e101107. Published online 2019 May 8. doi: 10.15252/embj.2018101107

PMCID:: PMC6576159

Abstract Article PDF–1.3M

Select item 625808016.

SAMHD1 Deficient Human Monocytes Autonomously Trigger Type I interferon

Alicia Martinez-Lopez, Marta Martin-Fernandez, Sofija Buta, Baek Kim, Dusan Bogunovic, Felipe Diaz-Griffero

Mol Immunol. Author manuscript; available in PMC 2019 Sep 1.

Published in final edited form as: Mol Immunol. 2018 Sep; 101: 450–460. Published online 2018 Aug 9. doi: 10.1016/j.molimm.2018.08.005

PMCID:: PMC6258080

Abstract Article PDF–762K

Select item 615063417.

Transcriptional regulation by promoters with enhancer function

Lan T. M. Dao, Salvatore Spicuglia

Transcription. 2018; 9(5): 307–314. Published online 2018 Jun 25. doi: 10.1080/21541264.2018.1486150

PMCID:: PMC6150634

Abstract Article PDF–989K

Select item 598414318.

PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway

Bhanu Kanth Manne, Patrick Münzer, Rachit Badolia, Britta Walker-Allgaier, Robert A Campbell, Elizabeth Middleton, Andrew S Weyrich, Satya P Kunapuli, Oliver Borst, Matthew T. Rondina

J Thromb Haemost. Author manuscript; available in PMC 2019 Jun 1.

Published in final edited form as: J Thromb Haemost. 2018 Jun; 16(6): 1211–1225. Published online 2018 May 8. doi: 10.1111/jth.14005