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Select item 113171271.

Structure-based characterization and compound identification of the wild-type THF class-II riboswitch

Chunyan Li, Xiaochen Xu, Zhi Geng, Luqian Zheng, Qianqian Song, Xin Shen, Jingjing Wu, Jin zhao, Hongcheng Li, Mengqi He, Xiaoqing Tai, Long Zhang, Jinbiao Ma, Yuhui Dong, Aiming Ren

Nucleic Acids Res. 2024 Aug 12; 52(14): 8454–8465. Published online 2024 May 20. doi: 10.1093/nar/gkae377

PMCID:: PMC11317127

Abstract Article PDF–4.4M

Select item 111602932.

Large diversity in transport‐mediated methotrexate resistance in human leukemia cell line CCRF‐CEM established in a high concentration of leucovorin

Satomi Asai, Hayato Miyachi, Hiroyuki Kobayashi, Yuzuru Takemura, Yasuhiko Ando

Cancer Sci. 2003 Feb; 94(2): 210–214. Published online 2005 Aug 19. doi: 10.1111/j.1349-7006.2003.tb01421.x

PMCID:: PMC11160293

Abstract Article PDF–134K

Select item 111583363.

Different histological types of non‐small cell lung cancer have distinct folate and DNA methylation levels

MingJi Jin, Kazuyuki Kawakami, Yousuke Fukui, Sayaka Tsukioka, Makoto Oda, Go Watanabe, Teiji Takechi, Toshinori Oka, Toshinari Minamoto

Cancer Sci. 2009 Dec; 100(12): 2325–2330. Published online 2009 Aug 25. doi: 10.1111/j.1349-7006.2009.01321.x

PMCID:: PMC11158336

Abstract Article PDF–269K

Select item 111582044.

Cyclin‐dependent kinase inhibitor SU9516 enhances sensitivity to methotrexate in human T‐cell leukemia Jurkat cells

Hitoji Uchiyama, Yoshihiro Sowa, Miki Wakada, Mayumi Yogosawa, Ryoko Nakanishi, Mano Horinaka, Chihiro Shimazaki, Masafumi Taniwaki, Toshiyuki Sakai

Cancer Sci. 2010 Mar; 101(3): 728–734. Published online 2009 Nov 27. doi: 10.1111/j.1349-7006.2009.01449.x

PMCID:: PMC11158204

Abstract Article PDF–339K

Select item 109389855.

19-base pair deletion polymorphism of the dihydrofolate reductase (DHFR) gene: maternal risk of Down syndrome and folate metabolism

Cristiani Cortez Mendes, Joice Matos Biselli, Bruna Lancia Zampieri, Eny Maria Goloni-Bertollo, Marcos Nogueira Eberlin, Renato Haddad, Maria Francesca Riccio, Hélio Vannucchi, Valdemir Melechco Carvalho, Érika Cristina Pavarino-Bertelli

Sao Paulo Med J. 2010; 128(4): 215–218. Published online 2010 Jul 1. doi: 10.1590/S1516-31802010000400008

PMCID:: PMC10938985

Abstract Article PDF–125K

Select item 91802086.

The Second Class of Tetrahydrofolate (THF-II) Riboswitches Recognizes the Tetrahydrofolic Acid Ligand via Local Conformation Changes

Minmin Zhang, Guangfeng Liu, Yunlong Zhang, Ting Chen, Shanshan Feng, Rujie Cai, Changrui Lu

Int J Mol Sci. 2022 Jun; 23(11): 5903. Published online 2022 May 25. doi: 10.3390/ijms23115903

PMCID:: PMC9180208

Abstract Article PDF–2.2M

Select item 88794137.

Role of active site loop dynamics in mediating ligand release from E. coli dihydrofolate reductase

Amrinder Singh, Robert Bryn Fenwick, H. Jane Dyson, Peter E. Wright

Biochemistry. Author manuscript; available in PMC 2022 Sep 7.

Published in final edited form as: Biochemistry. 2021 Sep 7; 60(35): 2663–2671. Published online 2021 Aug 24. doi: 10.1021/acs.biochem.1c00461

PMCID:: PMC8879413

Abstract Article PDF–1.1M

Select item 86082858.

Methionine synthase is essential for cancer cell proliferation in physiological folate environments

Mark R. Sullivan, Alicia M. Darnell, Montana F. Reilly, Tenzin Kunchok, Lena Joesch-Cohen, Daniel Rosenberg, Ahmed Ali, Matthew G. Rees, Jennifer A. Roth, Caroline A. Lewis, Matthew G. Vander Heiden

Nat Metab. Author manuscript; available in PMC 2022 May 18.

Published in final edited form as: Nat Metab. 2021 Nov; 3(11): 1500–1511. Published online 2021 Nov 18. doi: 10.1038/s42255-021-00486-5

PMCID:: PMC8608285

Abstract Article PDF–1.6M

Select item 76546199.

Aldh1l2 knockout mouse metabolomics links the loss of the mitochondrial folate enzyme to deregulation of a lipid metabolism observed in rare human disorder

Natalia I. Krupenko, Jaspreet Sharma, Peter Pediaditakis, Kristi L. Helke, Madeline S. Hall, Xiuxia Du, Susan Sumner, Sergey A. Krupenko

Hum Genomics. 2020; 14: 41. Published online 2020 Nov 9. doi: 10.1186/s40246-020-00291-3

PMCID:: PMC7654619

Abstract Article PDF–3.3M

Select item 725175910.

DJ-1 is a new prognostic marker and predicts chemotherapy efficacy in colorectal cancer

Weimin Wang, Haibo Wang, Liangliang Xiang, Tengyang Ni, Feng Jin, Jianliang Deng, Yunlei Zhang, Ishikawa Shintaro, Yan Zhou, Yanqing Liu

Oncol Rep. 2020 Jul; 44(1): 77–90. Published online 2020 Apr 23. doi: 10.3892/or.2020.7593

PMCID:: PMC7251759

Abstract Article PDF–1.7M

Select item 715476211.

Structures in Tetrahydrofolate Methylation in Desulfitobacterial Glycine Betaine Metabolism at Atomic Resolution

Thomas Badmann, Prof. Dr. Michael Groll

Chembiochem. 2020 Mar 16; 21(6): 776–779. Published online 2019 Nov 18. doi: 10.1002/cbic.201900515

PMCID:: PMC7154762

Abstract Article PDF–2.1M

Select item 707622012.

Impaired folate binding of serine hydroxymethyltransferase 8 from soybean underlies resistance to the soybean cyst nematode

David A. Korasick, Pramod K. Kandoth, John J. Tanner, Melissa G. Mitchum, Lesa J. Beamer

J Biol Chem. 2020 Mar 13; 295(11): 3708–3718. Published online 2020 Feb 2. doi: 10.1074/jbc.RA119.012256

PMCID:: PMC7076220

Abstract Article PDF–2.5M

Select item 679770713.

Cytosolic 10-formyltetrahydrofolate dehydrogenase regulates glycine metabolism in mouse liver

Natalia I. Krupenko, Jaspreet Sharma, Peter Pediaditakis, Baharan Fekry, Kristi L. Helke, Xiuxia Du, Susan Sumner, Sergey A. Krupenko

Sci Rep. 2019; 9: 14937. Published online 2019 Oct 17. doi: 10.1038/s41598-019-51397-1

PMCID:: PMC6797707

Abstract Article PDF–3.9M

Select item 674646514.

MtpB, a member of the MttB superfamily from the human intestinal acetogen Eubacterium limosum, catalyzes proline betaine demethylation

Jonathan W. Picking, Edward J. Behrman, Liwen Zhang, Joseph A. Krzycki

J Biol Chem. 2019 Sep 13; 294(37): 13697–13707. Published online 2019 Jul 24. doi: 10.1074/jbc.RA119.009886

PMCID:: PMC6746465

Abstract Article PDF–1.1M

Select item 668929715.

The Properties of 5-Methyltetrahydrofolate Dehydrogenase (MetF1) and Its Role in the Tetrahydrofolate-Dependent Dicamba Demethylation System in Rhizorhabdus dicambivorans Ndbn-20

Shigang Yao, Le Chen, Zhou Yang, Li Yao, Jianchun Zhu, Jiguo Qiu, Guoxiang Wang, Jian He

J Bacteriol. 2019 Sep 1; 201(17): e00096-19. Prepublished online 2019 Jun 17. Published online 2019 Aug 8. doi: 10.1128/JB.00096-19

PMCID:: PMC6689297

Abstract Article PDF–1.9M

Select item 661569416.

A flap motif in human serine hydroxymethyltransferase is important for structural stabilization, ligand binding, and control of product release

Sakunrat Ubonprasert, Juthamas Jaroensuk, Wichai Pornthanakasem, Nuntaporn Kamonsutthipaijit, Peerapong Wongpituk, Pitchayathida Mee-udorn, Thanyada Rungrotmongkol, Onuma Ketchart, Penchit Chitnumsub, Ubolsree Leartsakulpanich, Pimchai Chaiyen, Somchart Maenpuen

J Biol Chem. 2019 Jul 5; 294(27): 10490–10502. Published online 2019 May 22. doi: 10.1074/jbc.RA119.007454

PMCID:: PMC6615694

Abstract Article PDF–2.3M

Select item 661492017.

Responsive self-assembly of tectoRNAs with loop–receptor interactions from the tetrahydrofolate (THF) riboswitch

Charles Mitchell, Julio A Polanco, Laura DeWald, Dustin Kress, Luc Jaeger, Wade W Grabow

Nucleic Acids Res. 2019 Jul 9; 47(12): 6439–6451. Published online 2019 May 2. doi: 10.1093/nar/gkz304

PMCID:: PMC6614920

Abstract Article PDF–3.7M

Select item 656831318.

Mitochondrial One-Carbon Pathway Supports Cytosolic Folate Integrity in Cancer Cells

Yuxiang Zheng, Ting-Yu Lin, Gina Lee, Marcia N. Paddock, Jessica Momb, Zhe Cheng, Qian Li, Dennis L. Fei, Benjamin D. Stein, Shivan Ramsamooj, Guoan Zhang, John Blenis, Lewis C. Cantley

Cell. Author manuscript; available in PMC 2019 Nov 29.

Published in final edited form as: Cell. 2018 Nov 29; 175(6): 1546–1560.e17. doi: 10.1016/j.cell.2018.09.041