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Select item 111398771.

1-Methyltryptophan treatment ameliorates high-fat diet-induced depression in mice through reversing changes in perineuronal nets

Juntao Hu, Shanshan Zhang, Haoran Wu, Leilei Wang, Yuwen Zhang, Hongyang Gao, Meihui Li, Hong Ren, Honglei Xiao, Kun Guo, Wensheng Li, Qiong Liu

Transl Psychiatry. 2024; 14: 228. Published online 2024 May 30. doi: 10.1038/s41398-024-02938-4

PMCID:: PMC11139877

Abstract Article PDF–3.1M

Select item 110285672.

Effects of 1-methyltryptophan stereoisomers on IDO2 enzyme activity and IDO2-mediated arrest of human T cell proliferation

Feng Qian, Jianqun Liao, Jeannine Villella, Robert Edwards, Pawel Kalinski, Shashikant Lele, Protul Shrikant, Kunle Odunsi

Cancer Immunol Immunother. 2012 Nov; 61(11): 2013–2020. Published online 2012 Apr 22. doi: 10.1007/s00262-012-1265-x

PMCID:: PMC11028567

Abstract Article PDF–418K

Select item 108367633.

Indoximod-based chemo-immunotherapy for pediatric brain tumors: A first-in-children phase I trial

Theodore S Johnson, Tobey J MacDonald, Rafal Pacholczyk, Dolly Aguilera, Ahmad Al-Basheer, Manish Bajaj, Pratiti Bandopadhayay, Zuzana Berrong, Eric Bouffet, Robert C Castellino, Kathleen Dorris, Bree R Eaton, Natia Esiashvili, Jason R Fangusaro, Nicholas Foreman, Diana Fridlyand, Cole Giller, Ian M Heger, Chenbin Huang, Nadja Kadom, Eugene P Kennedy, Neevika Manoharan, William Martin, Colleen McDonough, Rebecca S Parker, Vijay Ramaswamy, Eric Ring, Amyn Rojiani, Ramses F Sadek, Sarthak Satpathy, Matthew Schniederjan, Amy Smith, Christopher Smith, Beena E Thomas, Rachel Vaizer, Kee Kiat Yeo, Manoj K Bhasin, David H Munn

Neuro Oncol. 2024 Feb; 26(2): 348–361. Published online 2023 Sep 16. doi: 10.1093/neuonc/noad174

PMCID:: PMC10836763

Abstract Article PDF–12M

Select item 104253004.

Aryl hydrocarbon receptor–kynurenine axis promotes oncogenic activity in BCP-ALL

Li-Ting Wang, Kwei-Yan Liu, Shen-Nien Wang, Ming-Hong Lin, Yu-Mei Liao, Pei-Chin Lin, Shau-Ku Huang, Shih-Hsien Hsu, Shyh-Shin Chiou

Cell Biol Toxicol. 2023; 39(4): 1471–1487. Published online 2022 Jun 10. doi: 10.1007/s10565-022-09734-0

PMCID:: PMC10425300

Abstract Article PDF–3.9M

Select item 82021045.

Phase II trial of the IDO pathway inhibitor indoximod plus pembrolizumab for the treatment of patients with advanced melanoma

Yousef Zakharia, Robert R McWilliams, Olivier Rixe, Joseph Drabick, Montaser F Shaheen, Kenneth F Grossmann, Ravindra Kolhe, Rafal Pacholczyk, Ramses Sadek, Lucinda L Tennant, Christopher M Smith, Eugene P Kennedy, Charles J Link Jr, Nicholas N Vahanian, Jiayi Yu, Steven S Shen, Erik L Brincks, Gabriela R Rossi, David Munn, Mohammed Milhem

J Immunother Cancer. 2021; 9(6): e002057. Published online 2021 Jun 11. doi: 10.1136/jitc-2020-002057

PMCID:: PMC8202104

Abstract Article PDF–1.3M

Select item 80230196.

Liposomal Delivery of Mitoxantrone and a Cholesteryl Indoximod Prodrug Provides Effective Chemo-Immunotherapy in Multiple Solid Tumors

Kuo-Ching Mei, Yu-Pei Liao, Jinhong Jiang, Michelle Chiang, Mercedeh Khazaieli, Xiangsheng Liu, Xiang Wang, Qi Liu, Chong Hyun Chang, Xiao Zhang, Juan Li, Ying Ji, Brenda Melano, Donatello Telesca, Tian Xia, Huan Meng, Andre E. Nel

ACS Nano. Author manuscript; available in PMC 2021 Oct 27.

Published in final edited form as: ACS Nano. 2020 Oct 27; 14(10): 13343–13366. Published online 2020 Sep 25. doi: 10.1021/acsnano.0c05194

PMCID:: PMC8023019

Abstract Article PDF–2.4M

Select item 76592697.

Suppression of azoxymethane‐induced colonic preneoplastic lesions in rats by 1‐methyltryptophan, an inhibitor of indoleamine 2,3‐dioxygenase

Kengo Ogawa, Takeshi Hara, Masahito Shimizu, Soranobu Ninomiya, Junji Nagano, Hiroyasu Sakai, Masato Hoshi, Hiroyasu Ito, Hisashi Tsurumi, Kuniaki Saito, Mitsuru Seishima, Takuji Tanaka, Hisataka Moriwaki

Cancer Sci. 2012 May; 103(5): 951–958. Published online 2012 Mar 6. doi: 10.1111/j.1349-7006.2012.02237.x

PMCID:: PMC7659269

Abstract Article PDF–466K

Select item 76457458.

Effect of Taxane Chemotherapy With or Without Indoximod in Metastatic Breast Cancer: A Randomized Clinical Trial

Veronica Mariotti, Hyo Han, Roohi Ismail-Khan, Shou-Ching Tang, Patrick Dillon, Alberto J. Montero, Andrew Poklepovic, Susan Melin, Nuhad K. Ibrahim, Eugene Kennedy, Nicholas Vahanian, Charles Link, Lucy Tennant, Shelly Schuster, Chris Smith, Oana Danciu, Paul Gilman, Hatem Soliman

JAMA Oncol. 2021 Jan; 7(1): 1–9. Published online 2020 Nov 5. doi: 10.1001/jamaoncol.2020.5572

Correction in:: JAMA Oncol. 2021 Jan; 7(1): 140.

PMCID:: PMC7645745

Abstract Article

Select item 74885469.

1-MT inhibits the invasion of CBP-resistant ovarian cancer cells via down-regulating IDO expression and re-activating immune cells function

Huihan Ma, Qian Qin, Jiaqing Mi, Qinmei Feng

BMC Pharmacol Toxicol. 2020; 21: 67. Published online 2020 Sep 11. doi: 10.1186/s40360-020-00439-w

PMCID:: PMC7488546

Abstract Article PDF–948K

Select item 748806310.

1-Methyl-D-tryptophan activates aryl hydrocarbon receptor, a pathway associated with bladder cancer progression

Luiz Henrique Gomes Matheus, Stephanie Vanin Dalmazzo, Rodrigo Barbosa Oliveira Brito, Lucas Alves Pereira, Robson José de Almeida, Cleber Pinto Camacho, Humberto Dellê

BMC Cancer. 2020; 20: 869. Published online 2020 Sep 9. doi: 10.1186/s12885-020-07371-6

PMCID:: PMC7488063

Abstract Article PDF–780K

Select item 725965611.

Increased effect of two-fraction radiotherapy in conjunction with IDO1 inhibition in experimental glioblastoma

Jonatan Ahlstedt, Elise Konradsson, Crister Ceberg, Henrietta Nittby Redebrandt

PLoS One. 2020; 15(5): e0233617. Published online 2020 May 29. doi: 10.1371/journal.pone.0233617

PMCID:: PMC7259656

Abstract Article PDF–3.9M

Select item 724922312.

Combined Effect of Antiretroviral Therapy and Blockade of IDO in SIV-Infected Rhesus Macaques

Adriano Boasso, Monica Vaccari, Dietmar Fuchs, Andrew W. Hardy, Wen-Po Tsai, Elzbieta Tryniszewska, Gene M. Shearer, Genoveffa Franchini

J Immunol. Author manuscript; available in PMC 2020 May 26.

Published in final edited form as: J Immunol. 2009 Apr 1; 182(7): 4313–4320. doi: 10.4049/jimmunol.0803314

PMCID:: PMC7249223

Abstract Article PDF–1.5M

Select item 708330913.

Assessment of clinical outcomes with immune checkpoint inhibitor therapy in melanoma patients with CDKN2A and TP53 pathogenic mutations

Thomas T. DeLeon, Daniel R. Almquist, Benjamin R. Kipp, Blake T. Langlais, Aaron Mangold, Jennifer L. Winters, Heidi E. Kosiorek, Richard W. Joseph, Roxana S. Dronca, Matthew S. Block, Robert R. McWilliams, Lisa A. Kottschade, Kandelaria M. Rumilla, Jesse S. Voss, Mahesh Seetharam, Aleksandar Sekulic, Svetomir N. Markovic, Alan H. Bryce

PLoS One. 2020; 15(3): e0230306. Published online 2020 Mar 20. doi: 10.1371/journal.pone.0230306

PMCID:: PMC7083309

Abstract Article PDF–1.1M

Select item 705986114.

The Immunomodulator 1-Methyltryptophan Drives Tryptophan Catabolism Toward the Kynurenic Acid Branch

Elisa Wirthgen, Anne K. Leonard, Christian Scharf, Grazyna Domanska

Front Immunol. 2020; 11: 313. Published online 2020 Feb 28. doi: 10.3389/fimmu.2020.00313

PMCID:: PMC7059861

Abstract Article PDF–1.5M

Select item 682878215.

Role of indoleamine 2,3-dioxygenase in testicular immune-privilege

Gisela S. Gualdoni, Patricia V. Jacobo, Cristian M. Sobarzo, Cecilia V. Pérez, María E. Matzkin, Christian Höcht, Mónica B. Frungieri, Marcelo Hill, Ignacio Anegon, Livia Lustig, Vanesa A. Guazzone

Sci Rep. 2019; 9: 15919. Published online 2019 Nov 4. doi: 10.1038/s41598-019-52192-8

PMCID:: PMC6828782

Abstract Article PDF–6.0M

Select item 677323016.

IDO1 depletion induces an anti-inflammatory response in macrophages in mice with chronic viral myocarditis

Gongliang Guo, Liqun Sun, Lili Yang, Haiming Xu

Cell Cycle. 2019; 18(20): 2598–2613. Published online 2019 Aug 15. doi: 10.1080/15384101.2019.1652471

PMCID:: PMC6773230

Abstract Article PDF–2.6M

Select item 661622317.

Co-treatment with interferon-γ and 1-methyl tryptophan ameliorates cardiac fibrosis through cardiac myofibroblasts apoptosis

Jun-Won Lee, Ji Eun Oh, Ki-Jong Rhee, Byung-Su Yoo, Young Woo Eom, Sang Wook Park, Ji Hyun Lee, Jung-Woo Son, Young Jin Youn, Min-Soo Ahn, Sung-Gyun Ahn, Jang-Young Kim, Seung-Hwan Lee, Junghan Yoon

Mol Cell Biochem. 2019; 458(1): 197–205. Published online 2019 Apr 22. doi: 10.1007/s11010-019-03542-7

PMCID:: PMC6616223

Abstract Article PDF–2.9M

Select item 658265918.

Indoleamine 2,3-Dioxygenase Activity in Chlamydia muridarum and Chlamydia pneumoniae Infected Mouse Lung Tissues

Dezső P. Virok, Tímea Raffai, Dávid Kókai, Dóra Paróczai, Anita Bogdanov, Gábor Veres, László Vécsei, Szilárd Poliska, László Tiszlavicz, Ferenc Somogyvári, Valéria Endrész, Katalin Burián

Front Cell Infect Microbiol. 2019; 9: 192. Published online 2019 Jun 12. doi: 10.3389/fcimb.2019.00192

PMCID:: PMC6582659

Abstract Article PDF–2.5M

Select item 656633519.

Formation of the Immunosuppressive Microenvironment of Classic Hodgkin Lymphoma and Therapeutic Approaches to Counter It

Donatella Aldinucci, Cinzia Borghese, Naike Casagrande

Int J Mol Sci. 2019 May; 20(10): 2416. Published online 2019 May 15. doi: 10.3390/ijms20102416

PMCID:: PMC6566335

Abstract Article PDF–1.5M

Select item 651370720.

Dual Functional Immunostimulatory Polymeric Prodrug Carrier with Pendent Indoximod for Enhanced Cancer Immunochemotherapy

Zhuoya Wan, Jingjing Sun, Jieni Xu, Pearl Moharil, Jing Chen, Junchi Xu, Junjie Zhu, Jiang Li, Yixian Huang, Pengfei Xu, Xiaochao Ma, Wen Xie, Binfeng Lu, Song Li

Acta Biomater. Author manuscript; available in PMC 2020 May 1.

Published in final edited form as: Acta Biomater. 2019 May; 90: 300–313. Published online 2019 Mar 28. doi: 10.1016/j.actbio.2019.03.048

PMCID:: PMC6513707

Abstract Article PDF–2.8M

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