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Select item 40078421.

Allosteric IGF-1R Inhibitors

Timo Heinrich, Ulrich Grädler, Henning Böttcher, Andree Blaukat, Adam Shutes

ACS Med Chem Lett. 2010 Aug 12; 1(5): 199–203. Published online 2010 May 18. doi: 10.1021/ml100044h

PMCID:: PMC4007842

Abstract Article PDF–4.7M

Select item 33209982.

Cross-talk between Integrin α6β4 and Insulin-like Growth Factor-1 Receptor (IGF1R) through Direct α6β4 Binding to IGF1 and Subsequent α6β4-IGF1-IGF1R Ternary Complex Formation in Anchorage-independent Conditions

Masaaki Fujita, Katsuaki Ieguchi, Parastoo Davari, Satoshi Yamaji, Yukimasa Taniguchi, Kiyotoshi Sekiguchi, Yoko K. Takada, Yoshikazu Takada

J Biol Chem. 2012 Apr 6; 287(15): 12491–12500. Published online 2012 Feb 20. doi: 10.1074/jbc.M111.304170

PMCID:: PMC3320998

Abstract Article PDF–1.8M

Select item 33088913.

Polyubiquitination of Insulin-like Growth Factor I Receptor (IGF-IR) Activation Loop Promotes Antibody-induced Receptor Internalization and Down-regulation

Yifan Mao, Yonglei Shang, Victoria C. Pham, James A. Ernst, Jennie R. Lill, Suzie J. Scales, Jiping Zha

J Biol Chem. 2011 Dec 2; 286(48): 41852–41861. Published online 2011 Oct 12. doi: 10.1074/jbc.M111.288514

PMCID:: PMC3308891

Abstract Article PDF–3.2M

Select item 28931564.

Development and Validation of a Method for Profiling Post-Translational Modification Activities Using Protein Microarrays

Sonia V. del Rincón, Jeff Rogers, Martin Widschwendter, Dahui Sun, Hans B. Sieburg, Charles Spruck

PLoS One. 2010; 5(6): e11332. Published online 2010 Jun 28. doi: 10.1371/journal.pone.0011332

PMCID:: PMC2893156

Abstract Article PDF–579K

Select item 27820045.

The Direct Binding of Insulin-like Growth Factor-1 (IGF-1) to Integrin αvβ3 Is Involved in IGF-1 Signaling

Jun Saegusa, Satoshi Yamaji, Katsuaki Ieguchi, Chun-Yi Wu, Kit S. Lam, Fu-Tong Liu, Yoko K. Takada, Yoshikazu Takada

J Biol Chem. 2009 Sep 4; 284(36): 24106–24114. Published online 2009 Jul 3. doi: 10.1074/jbc.M109.013201

PMCID:: PMC2782004

Abstract Article PDF–2.9M

Select item 27127196.

Patterns of somatic mutation in human cancer genomes

Christopher Greenman, Philip Stephens, Raffaella Smith, Gillian L. Dalgliesh, Christopher Hunter, Graham Bignell, Helen Davies, Jon Teague, Adam Butler, Claire Stevens, Sarah Edkins, Sarah O'Meara, Imre Vastrik, Esther E. Schmidt, Tim Avis, Syd Barthorpe, Gurpreet Bhamra, Gemma Buck, Bhudipa Choudhury, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Kris Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jon Hinton, Andy Jenkinson, David Jones, Andy Menzies, Tatiana Mironenko, Janet Perry, Keiran Raine, Dave Richardson, Rebecca Shepherd, Alexandra Small, Calli Tofts, Jennifer Varian, Tony Webb, Sofie West, Sara Widaa, Andy Yates, Daniel P. Cahill, David N. Louis, Peter Goldstraw, Andrew G. Nicholson, Francis Brasseur, Leendert Looijenga, Barbara L. Weber, Yoke-Eng Chiew, Anna deFazio, Mel F. Greaves, Anthony R. Green, Peter Campbell, Ewan Birney, Douglas F. Easton, Georgia Chenevix-Trench, Min-Han Tan, Sok Kean Khoo, Bin Tean Teh, Siu Tsan Yuen, Suet Yi Leung, Richard Wooster, P. Andrew Futreal, Michael R. Stratton

Nature. Author manuscript; available in PMC 2009 Jul 20.

Published in final edited form as: Nature. 2007 Mar 8; 446(7132): 153–158. doi: 10.1038/nature05610

PMCID:: PMC2712719

Abstract Article PDF–867K

Select item 27091997.

Large-scale Proteomics Analysis of the Human Kinome

Felix S. Oppermann, Florian Gnad, Jesper V. Olsen, Renate Hornberger, Zoltán Greff, György Kéri, Matthias Mann, Henrik Daub

Mol Cell Proteomics. 2009 Jul; 8(7): 1751–1764. Published online 2009 Apr 15. doi: 10.1074/mcp.M800588-MCP200

PMCID:: PMC2709199

Abstract Article PDF–993K

Select item 24862738.

Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor

Jinhua Wu, Wanqing Li, Barbara P Craddock, Kenneth W Foreman, Mark J Mulvihill, Qun-sheng Ji, W Todd Miller, Stevan R Hubbard

EMBO J. 2008 Jul 23; 27(14): 1985–1994. Published online 2008 Jun 19. doi: 10.1038/emboj.2008.116

PMCID:: PMC2486273

Abstract Article PDF–1.2M

Select item 12188559.

14-3-3 proteins interact with the insulin-like growth factor receptor but not the insulin receptor.

R W Furlanetto, B R Dey, W Lopaczynski, S P Nissley

Biochem J. 1997 Nov 1; 327(Pt 3): 765–771. doi: 10.1042/bj3270765

PMCID:: PMC1218855

Summary PDF–365K

Select item 121878310.

Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting.

E M Bailyes, B T Navé, M A Soos, S R Orr, A C Hayward, K Siddle

Biochem J. 1997 Oct 1; 327(Pt 1): 209–215. doi: 10.1042/bj3270209

PMCID:: PMC1218783

Summary PDF–339K

Select item 116714611.

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

A Ullrich, A Gray, A W Tam, T Yang-Feng, M Tsubokawa, C Collins, W Henzel, T Le Bon, S Kathuria, E Chen, et al.

EMBO J. 1986 Oct; 5(10): 2503–2512. doi: 10.1002/j.1460-2075.1986.tb04528.x

PMCID:: PMC1167146

Summary Page Browse PDF–3.4M

Select item 113229012.

Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity.

M A Soos, C E Field, K Siddle

Biochem J. 1993 Mar 1; 290(Pt 2): 419–426. doi: 10.1042/bj2900419

PMCID:: PMC1132290

Summary Page Browse PDF–1.7M

Select item 52892813.

The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)

Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504

Correction in:: Genome Res. 2006 Jun; 16(6): 804.

PMCID:: PMC528928

Abstract Article PDF–140K

Select item 16621414.

Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor

Leonard Girnita, Ada Girnita, Olle Larsson

Proc Natl Acad Sci U S A. 2003 Jul 8; 100(14): 8247–8252. Published online 2003 Jun 23. doi: 10.1073/pnas.1431613100

PMCID:: PMC166214

Abstract Article PDF–476K

Select item 13369815.

RACK1, an Insulin-Like Growth Factor I (IGF-I) Receptor-Interacting Protein, Modulates IGF-I-Dependent Integrin Signaling and Promotes Cell Spreading and Contact with Extracellular Matrix

Ulrich Hermanto, Cong S. Zong, Weiqun Li, Lu-Hai Wang

Mol Cell Biol. 2002 Apr; 22(7): 2345–2365. doi: 10.1128/MCB.22.7.2345-2365.2002

PMCID:: PMC133698

Abstract Article PDF–977K

Select item 8456716.

Grb10, a Positive, Stimulatory Signaling Adapter in Platelet-Derived Growth Factor BB-, Insulin-Like Growth Factor I-, and Insulin-Mediated Mitogenesis

Jian Wang, Heping Dai, Nasim Yousaf, Mustapha Moussaif, Youping Deng, Amale Boufelliga, O. Rama Swamy, Michelle E. Leone, Heimo Riedel

Mol Cell Biol. 1999 Sep; 19(9): 6217–6228. doi: 10.1128/mcb.19.9.6217

PMCID:: PMC84567

Abstract Article PDF–1.6M

Select item 702890117.

Label-free quantitative identification of abnormally ubiquitinated proteins as useful biomarkers for human lung squamous cell carcinomas

Miaolong Lu, Wei Chen, Wei Zhuang, Xianquan Zhan

EPMA J. 2020 Mar; 11(1): 73–94. Published online 2020 Jan 4. doi: 10.1007/s13167-019-00197-8

PMCID:: PMC7028901

Abstract Article PDF–3.7M

Select item 695922218.

Combined network pharmacology and virtual reverse pharmacology approaches for identification of potential targets to treat vascular dementia

Alexey A. Lagunin, Sergey M. Ivanov, Tatyana A. Gloriozova, Pavel V. Pogodin, Dmitry A. Filimonov, Sandeep Kumar, Rajesh K. Goel

Sci Rep. 2020; 10: 257. Published online 2020 Jan 14. doi: 10.1038/s41598-019-57199-9

PMCID:: PMC6959222

Abstract Article PDF–3.3M

Select item 671364319.

Cytosolic phospholipase A2α modulates cell-matrix adhesion via the FAK/paxillin pathway in hepatocellular carcinoma

Piao Guo, Yuchao He, Lu Chen, Lisha Qi, Dongming Liu, Ziye Chen, Manyu Xiao, Liwei Chen, Yi Luo, Ning Zhang, Hua Guo

Cancer Biol Med. 2019 May; 16(2): 377–390. doi: 10.20892/j.issn.2095-3941.2018.0386

PMCID:: PMC6713643

Abstract Article PDF–16M

Select item 669316520.

Genotyping, generation and proteomic profiling of the first human autosomal dominant osteopetrosis type II-specific induced pluripotent stem cells

Minglin Ou, Chunhong Li, Donge Tang, Wen Xue, Yong Xu, Peng Zhu, Bo Li, Jiansheng Xie, Jiejing Chen, Weiguo Sui, Lianghong Yin, Yong Dai

Stem Cell Res Ther. 2019; 10: 251. Published online 2019 Aug 14. doi: 10.1186/s13287-019-1369-8

PMCID:: PMC6693165

Abstract Article PDF–11M

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