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Select item 41447371.

RHEX, a novel regulator of human erythroid progenitor cell expansion and erythroblast development

Rakesh Verma, Su Su, Donald J. McCrann, Jennifer M. Green, Karen Leu, Peter R. Young, Peter J. Schatz, Jeffrey C. Silva, Matthew P. Stokes, Don M. Wojchowski

J Exp Med. 2014 Aug 25; 211(9): 1715–1722. doi: 10.1084/jem.20130624

Correction in:: J Exp Med. 2015 Jun 1; 212(6): 971.

PMCID:: PMC4144737

Abstract Article PDF–2.2M

Select item 37851472.

JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin

Mark A. Dawson, Andrew J. Bannister, Berthold Göttgens, Samuel D. Foster, Till Bartke, Anthony R. Green, Tony Kouzarides

Nature. Author manuscript; available in PMC 2013 Sep 27.

Published in final edited form as: Nature. 2009 Oct 8; 461(7265): 819–822. Published online 2009 Sep 27. doi: 10.1038/nature08448

PMCID:: PMC3785147

Abstract Article PDF–3.6M

Select item 31604903.

Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control

H Jäkel, C Weinl, L Hengst

Oncogene. Author manuscript; available in PMC 2012 Feb 11.

Published in final edited form as: Oncogene. 2011 Aug 11; 30(32): 3502–3512. Published online 2011 Mar 21. doi: 10.1038/onc.2011.68

PMCID:: PMC3160490

Abstract Article PDF–1.0M

Select item 30602394.

Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses

Daniel C. Berry, Hui Jin, Avijit Majumdar, Noa Noy

Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11): 4340–4345. Published online 2011 Feb 23. doi: 10.1073/pnas.1011115108

PMCID:: PMC3060239

Abstract Article PDF–1.0M

Select item 30384095.

Heme Controls the Regulation of Protein Tyrosine Kinases Jak2 and Src

Xiao Yao, Parimaladevi Balamurugan, Aaron Arvey, Christina Leslie, Li Zhang

Biochem Biophys Res Commun. Author manuscript; available in PMC 2011 Dec 3.

Published in final edited form as: Biochem Biophys Res Commun. 2010 Dec 3; 403(1): 30–35. Published online 2010 Oct 29. doi: 10.1016/j.bbrc.2010.10.101

PMCID:: PMC3038409

Abstract Article PDF–732K

Select item 28738346.

JAK2 Exon 12 Mutations in Polycythemia Vera and Idiopathic Erythrocytosis

Linda M. Scott, Wei Tong, Ross L. Levine, Mike A. Scott, Philip A. Beer, Michael R. Stratton, P. Andrew Futreal, Wendy N. Erber, Mary Frances McMullin, Claire N. Harrison, Alan J. Warren, D. Gary Gilliland, Harvey F. Lodish, Anthony R. Green

N Engl J Med. Author manuscript; available in PMC 2010 May 20.

Published in final edited form as: N Engl J Med. 2007 Feb 1; 356(5): 459–468. doi: 10.1056/NEJMoa065202

PMCID:: PMC2873834

Abstract Article PDF–1.9M

Select item 27826967.

Janus kinases in immune cell signaling

Kamran Ghoreschi, Arian Laurence, John J. O’Shea

Immunol Rev. Author manuscript; available in PMC 2010 Mar 1.

Published in final edited form as: Immunol Rev. 2009 Mar; 228(1): 273–287. doi: 10.1111/j.1600-065X.2008.00754.x

PMCID:: PMC2782696

Abstract Article PDF–187K

Select item 27340818.

DNA sequence and analysis of human chromosome 9

S. J. Humphray, K. Oliver, A. R. Hunt, R. W. Plumb, J. E. Loveland, K. L. Howe, T. D. Andrews, S. Searle, S. E. Hunt, C. E. Scott, M. C. Jones, R. Ainscough, J. P. Almeida, K. D. Ambrose, R. I. S. Ashwell, A. K. Babbage, S. Babbage, C. L. Bagguley, J. Bailey, R. Banerjee, D. J. Barker, K. F. Barlow, K. Bates, H. Beasley, O. Beasley, C. P. Bird, S. Bray-Allen, A. J. Brown, J. Y. Brown, D. Burford, W. Burrill, J. Burton, C. Carder, N. P. Carter, J. C. Chapman, Y. Chen, G. Clarke, S. Y. Clark, C. M. Clee, S. Clegg, R. E. Collier, N. Corby, M. Crosier, A. T. Cummings, J. Davies, P. Dhami, M. Dunn, I. Dutta, L. W. Dyer, M. E. Earthrowl, L. Faulkner, C. J. Fleming, A. Frankish, J. A. Frankland, L. French, D. G. Fricker, P. Garner, J. Garnett, J. Ghori, J. G. R. Gilbert, C. Glison, D. V. Grafham, S. Gribble, C. Griffiths, S. Griffiths-Jones, R. Grocock, J. Guy, R. E. Hall, S. Hammond, J. L. Harley, E. S. I. Harrison, E. A. Hart, P. D. Heath, C. D. Henderson, B. L. Hopkins, P. J. Howard, P. J. Howden, E. Huckle, C. Johnson, D. Johnson, A. A. Joy, M. Kay, S. Keenan, J. K. Kershaw, A. M. Kimberley, A. King, A. Knights, G. K. Laird, C. Langford, S. Lawlor, D. A. Leongamornlert, M. Leversha, C. Lloyd, D. M. Lloyd, J. Lovell, S. Martin, M. Mashreghi-Mohammadi, L. Matthews, S. McLaren, K. E. McLay, A. McMurray, S. Milne, T. Nickerson, J. Nisbett, G. Nordsiek, A. V. Pearce, A. I. Peck, K. M. Porter, R. Pandian, S. Pelan, B. Phillimore, S. Povey, Y. Ramsey, V. Rand, M. Scharfe, H. K. Sehra, R. Shownkeen, S. K. Sims, C. D. Skuce, M. Smith, C. A. Steward, D. Swarbreck, N. Sycamore, J. Tester, A. Thorpe, A. Tracey, A. Tromans, D. W. Thomas, M. Wall, J. M. Wallis, A. P. West, S. L. Whitehead, D. L. Willey, S. A. Williams, L. Wilming, P. W. Wray, L. Young, J. L. Ashurst, A. Coulson, H. Blöcker, R. Durbin, J. E. Sulston, T. Hubbard, M. J. Jackson, D. R. Bentley, S. Beck, J. Rogers, I. Dunham

Nature. Author manuscript; available in PMC 2009 Aug 28.

Published in final edited form as: Nature. 2004 May 27; 429(6990): 369–374. doi: 10.1038/nature02465

PMCID:: PMC2734081

Abstract Article PDF–1006K

Select item 27127199.

Patterns of somatic mutation in human cancer genomes

Christopher Greenman, Philip Stephens, Raffaella Smith, Gillian L. Dalgliesh, Christopher Hunter, Graham Bignell, Helen Davies, Jon Teague, Adam Butler, Claire Stevens, Sarah Edkins, Sarah O'Meara, Imre Vastrik, Esther E. Schmidt, Tim Avis, Syd Barthorpe, Gurpreet Bhamra, Gemma Buck, Bhudipa Choudhury, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Kris Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jon Hinton, Andy Jenkinson, David Jones, Andy Menzies, Tatiana Mironenko, Janet Perry, Keiran Raine, Dave Richardson, Rebecca Shepherd, Alexandra Small, Calli Tofts, Jennifer Varian, Tony Webb, Sofie West, Sara Widaa, Andy Yates, Daniel P. Cahill, David N. Louis, Peter Goldstraw, Andrew G. Nicholson, Francis Brasseur, Leendert Looijenga, Barbara L. Weber, Yoke-Eng Chiew, Anna deFazio, Mel F. Greaves, Anthony R. Green, Peter Campbell, Ewan Birney, Douglas F. Easton, Georgia Chenevix-Trench, Min-Han Tan, Sok Kean Khoo, Bin Tean Teh, Siu Tsan Yuen, Suet Yi Leung, Richard Wooster, P. Andrew Futreal, Michael R. Stratton

Nature. Author manuscript; available in PMC 2009 Jul 20.

Published in final edited form as: Nature. 2007 Mar 8; 446(7132): 153–158. doi: 10.1038/nature05610

PMCID:: PMC2712719

Abstract Article PDF–867K

Select item 143451510.

The JAK2 V617F mutation occurs in hematopoietic stem cells in polycythemia vera and predisposes toward erythroid differentiation

Catriona H. M. Jamieson, Jason Gotlib, Jeffrey A. Durocher, Mark P. Chao, M. Rajan Mariappan, Marla Lay, Carol Jones, James L. Zehnder, Stan L. Lilleberg, Irving L. Weissman

Proc Natl Acad Sci U S A. 2006 Apr 18; 103(16): 6224–6229. Published online 2006 Apr 7. doi: 10.1073/pnas.0601462103

PMCID:: PMC1434515

Abstract Article PDF–1.6M

Select item 701808511.

In-silico simulated prototype-patients using TPMS technology to study a potential adverse effect of sacubitril and valsartan

Guillem Jorba, Joaquim Aguirre-Plans, Valentin Junet, Cristina Segú-Vergés, José Luis Ruiz, Albert Pujol, Narcís Fernández-Fuentes, José Manuel Mas, Baldo Oliva

PLoS One. 2020; 15(2): e0228926. Published online 2020 Feb 13. doi: 10.1371/journal.pone.0228926

PMCID:: PMC7018085

Abstract Article PDF–1.3M

Select item 685367512.

A decision-theoretic approach to the evaluation of machine learning algorithms in computational drug discovery

Oliver P Watson, Isidro Cortes-Ciriano, Aimee R Taylor, James A Watson

Bioinformatics. 2019 Nov 15; 35(22): 4656–4663. Published online 2019 May 9. doi: 10.1093/bioinformatics/btz293

PMCID:: PMC6853675

Abstract Article PDF–314K

Select item 679145813.

Constitutively active GSK3β as a means to bolster dendritic cell functionality in the face of tumour-mediated immune suppression

Marta López González, Dinja Oosterhoff, Jelle J. Lindenberg, Ioanna Milenova, Sinead M. Lougheed, Tania Martiáñez, Henk Dekker, Dafne Carolina Alves Quixabeira, Basav Hangalapura, Jos Joore, Sander R. Piersma, Victor Cervera-Carrascon, Joao Manuel Santos, Rik J. Scheper, Henk M.W. Verheul, Connie R. Jiménez, Rieneke Van De Ven, Akseli Hemminki, Victor W. Van Beusechem, Tanja D. De Gruijl

Oncoimmunology. 2019; 8(10): e1631119. Published online 2019 Jul 19. doi: 10.1080/2162402X.2019.1631119

PMCID:: PMC6791458

Abstract Article PDF–5.6M

Select item 677404414.

A Network Pharmacology Study of the Multi-Targeting Profile of an Antiarrhythmic Chinese Medicine Xin Su Ning

Taiyi Wang, Hamish Streeter, Xuan Wang, Ujang Purnama, Ming Lyu, Carolyn Carr, Yu-ling Ma

Front Pharmacol. 2019; 10: 1138. Published online 2019 Sep 25. doi: 10.3389/fphar.2019.01138

PMCID:: PMC6774044

Abstract Article PDF–5.7M

Select item 671364315.

Cytosolic phospholipase A2α modulates cell-matrix adhesion via the FAK/paxillin pathway in hepatocellular carcinoma

Piao Guo, Yuchao He, Lu Chen, Lisha Qi, Dongming Liu, Ziye Chen, Manyu Xiao, Liwei Chen, Yi Luo, Ning Zhang, Hua Guo

Cancer Biol Med. 2019 May; 16(2): 377–390. doi: 10.20892/j.issn.2095-3941.2018.0386

PMCID:: PMC6713643

Abstract Article PDF–16M

Select item 666177916.

Three new compounds with nitric oxide inhibitory activity from Tirpitzia sinensis, an ethnomedicinal plant from Southwest China

Ronghui Gu, Yuehu Wang, Shibiao Wu, Yeling Wang, Ping Li, Li Xu, Yue Zhou, Ze’e Chen, Edward J. Kennelly, Chunlin Long

BMC Chem. 2019 Dec; 13(1): 47. Published online 2019 Apr 1. doi: 10.1186/s13065-019-0568-9

PMCID:: PMC6661779

Abstract Article PDF–1.9M

Select item 663652317.

Network Pharmacology-Based Prediction of the Active Compounds, Potential Targets, and Signaling Pathways Involved in Danshiliuhao Granule for Treatment of Liver Fibrosis

Yueying Tao, Kunming Tian, Ji Chen, Danfeng Tan, Yan Liu, Yongai Xiong, Zehui Chen, Yingbiao Tian

Evid Based Complement Alternat Med. 2019; 2019: 2630357. Published online 2019 Jul 3. doi: 10.1155/2019/2630357

PMCID:: PMC6636523

Abstract Article PDF–10M

Select item 658252118.

KekuleScope: prediction of cancer cell line sensitivity and compound potency using convolutional neural networks trained on compound images

Isidro Cortés-Ciriano, Andreas Bender

J Cheminform. 2019; 11: 41. Published online 2019 Jun 19. doi: 10.1186/s13321-019-0364-5

PMCID:: PMC6582521

Abstract Article PDF–2.0M

Select item 643489519.

Deciphering the mechanism of Indirubin and its derivatives in the inhibition of Imatinib resistance using a “drug target prediction-gene microarray analysis-protein network construction” strategy

Huayao Li, Lijuan Liu, Jing Zhuang, Cun Liu, Chao Zhou, Jing Yang, Chundi Gao, Gongxi Liu, Changgang Sun

BMC Complement Altern Med. 2019; 19: 75. Published online 2019 Mar 25. doi: 10.1186/s12906-019-2471-2

PMCID:: PMC6434895

Abstract Article PDF–4.3M

Select item 636390720.

Alchemical Grid Dock (AlGDock) calculations in the D3R Grand Challenge 3: Binding Free Energies between Flexible Ligands and Rigid Receptors

Bing Xie, David D. L. Minh

J Comput Aided Mol Des. Author manuscript; available in PMC 2020 Jan 1.

Published in final edited form as: J Comput Aided Mol Des. 2019 Jan; 33(1): 61–69. Published online 2018 Aug 6. doi: 10.1007/s10822-018-0143-9

PMCID:: PMC6363907

Abstract Article PDF–861K

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