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Select item 60371991.

Squalene Synthase Deficiency: Clinical, Biochemical, and Molecular Characterization of a Defect in Cholesterol Biosynthesis

David Coman, Lisenka E.L.M. Vissers, Lisa G. Riley, Michael P. Kwint, Roxanna Hauck, Janet Koster, Sinje Geuer, Sarah Hopkins, Barbra Hallinan, Larry Sweetman, Udo F.H. Engelke, T. Andrew Burrow, John Cardinal, James McGill, Anita Inwood, Christine Gurnsey, Hans R. Waterham, John Christodoulou, Ron A. Wevers, James Pitt

Am J Hum Genet. 2018 Jul 5; 103(1): 125–130. Published online 2018 Jun 14. doi: 10.1016/j.ajhg.2018.05.004

PMCID:: PMC6037199

Abstract Article PDF–862K

Select item 30395702.

Initial characterization of the human central proteome

Thomas R Burkard, Melanie Planyavsky, Ines Kaupe, Florian P Breitwieser, Tilmann Bürckstümmer, Keiryn L Bennett, Giulio Superti-Furga, Jacques Colinge

BMC Syst Biol. 2011; 5: 17. Published online 2011 Jan 26. doi: 10.1186/1752-0509-5-17

PMCID:: PMC3039570

Abstract Article PDF–2.3M

Select item 5289283.

The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)

Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504

Correction in:: Genome Res. 2006 Jun; 16(6): 804.

PMCID:: PMC528928

Abstract Article PDF–140K

Select item 3596454.

Conservation between human and fungal squalene synthetases: similarities in structure, function, and regulation.

G W Robinson, Y H Tsay, B K Kienzle, C A Smith-Monroy, R W Bishop

Mol Cell Biol. 1993 May; 13(5): 2706–2717. doi: 10.1128/mcb.13.5.2706

PMCID:: PMC359645

Summary Page Browse PDF–2.6M

Select item 67637915.

Systematic Affinity Purification Coupled to Mass Spectrometry Identified p62 as Part of the Cannabinoid Receptor CB2 Interactome

Ahmed Sharaf, Leonore Mensching, Christina Keller, Sebastian Rading, Marina Scheffold, Lysann Palkowitsch, Nevena Djogo, Meriem Rezgaoui, Hans A. Kestler, Barbara Moepps, Antonio Virgilio Failla, Meliha Karsak

Front Mol Neurosci. 2019; 12: 224. Published online 2019 Sep 20. doi: 10.3389/fnmol.2019.00224

PMCID:: PMC6763791

Abstract Article PDF–3.6M

Select item 66701096.

A Neighboring Aromatic-Aromatic Amino Acid Combination Governs Activity Divergence between Tomato Phytoene Synthases

Hongbo Cao, Hongmei Luo, Hui Yuan, Mohamed A. Eissa, Theodore W. Thannhauser, Ralf Welsch, Yu-Jin Hao, Lailiang Cheng, Li Li

Plant Physiol. 2019 Aug; 180(4): 1988–2003. Published online 2019 Jun 20. doi: 10.1104/pp.19.00384

PMCID:: PMC6670109

Abstract Article PDF–2.7M

Select item 64757987.

Hsp27 Responds to and Facilitates Enterovirus A71 Replication by Enhancing Viral Internal Ribosome Entry Site-Mediated Translation

Xuelian Dan, Qianya Wan, Lina Yi, Jing Lu, Yang Jiao, Huangcan Li, Dan Song, Ying Chen, Hongxi Xu, Ming-Liang He

J Virol. 2019 May 1; 93(9): e02322-18. Prepublished online 2019 Feb 27. Published online 2019 Apr 17. doi: 10.1128/JVI.02322-18

PMCID:: PMC6475798

Abstract Article PDF–3.9M

Select item 61096018.

ANGIOGENIC AND IMMUNOLOGIC PROTEINS IDENTIFIED BY DEEP PROTEOMIC PROFILING OF HUMAN RETINAL AND CHOROIDAL VASCULAR ENDOTHELIAL CELLS: POTENTIAL TARGETS FOR NEW BIOLOGIC DRUGS

Justine R. Smith, Larry L. David, Binoy Appukuttan, Phillip A. Wilmarth

Am J Ophthalmol. Author manuscript; available in PMC 2019 Sep 1.

Published in final edited form as: Am J Ophthalmol. 2018 Sep; 193: 197–229. Published online 2018 Mar 17. doi: 10.1016/j.ajo.2018.03.020

PMCID:: PMC6109601

Abstract Article PDF–826K

Select item 60724339.

Acetaminophen-induced S-nitrosylation and S-sulfenylation signalling in 3D cultured hepatocarcinoma cell spheroids

Katarzyna Wojdyla, Krzysztof Wrzesinski, James Williamson, Stephen J. Fey, Adelina Rogowska-Wrzesinska

Toxicol Res (Camb) 2016 May 1; 5(3): 905–920. Published online 2016 Mar 2. doi: 10.1039/c5tx00469a

PMCID:: PMC6072433

Abstract Article PDF–1.7M

Select item 600468710.

Quantitative proteomic analysis of the miR-148a-associated mechanisms of metastasis in non-small cell lung cancer

Dandan Chu, Jing Li, Hechun Lin, Xiao Zhang, Hongyu Pan, Lei Liu, Tao Yu, Mingxia Yan, Ming Yao

Oncol Lett. 2018 Jun; 15(6): 9941–9952. Published online 2018 Apr 26. doi: 10.3892/ol.2018.8581

PMCID:: PMC6004687

Abstract Article PDF–1.4M

Select item 598277411.

PPP2R1A regulated by PAX3/FOXO1 fusion contributes to the acquisition of aggressive behavior in PAX3/FOXO1-positive alveolar rhabdomyosarcoma

Keisuke Akaike, Yoshiyuki Suehara, Shinji Kohsaka, Takuo Hayashi, Yu Tanabe, Saiko Kazuno, Kenta Mukaihara, Midori Toda-Ishii, Taisei Kurihara, Youngji Kim, Taketo Okubo, Yasuhide Hayashi, Kazuya Takamochi, Fumiyuki Takahashi, Kazuo Kaneko, Marc Ladanyi, Tsuyoshi Saito

Oncotarget. 2018 May 18; 9(38): 25206–25215. Published online 2018 May 18. doi: 10.18632/oncotarget.25392

PMCID:: PMC5982774

Abstract Article PDF–1.6M

Select item 571558212.

Is systems pharmacology ready to impact upon therapy development? A study on the cholesterol biosynthesis pathway

Helen E Benson, Steven Watterson, Joanna L Sharman, Chido P Mpamhanga, Andrew Parton, Christopher Southan, Anthony J Harmar, Peter Ghazal

Br J Pharmacol. 2017 Dec; 174(23): 4362–4382. Published online 2017 Nov 26. doi: 10.1111/bph.14037

PMCID:: PMC5715582

Abstract Article PDF–1.1M

Select item 565066613.

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Enzymes

Stephen PH Alexander, Doriano Fabbro, Eamonn Kelly, Neil V Marrion, John A Peters, Elena Faccenda, Simon D Harding, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators

Br J Pharmacol. 2017 Dec; 174(Suppl Suppl 1): S272–S359. Published online 2017 Oct 21. doi: 10.1111/bph.13877

PMCID:: PMC5650666

Abstract Article PDF–1.8M

Select item 538058114.

Systematic Analysis of Cell-Type Differences in the Epithelial Secretome Reveals Insights into the Pathogenesis of RSV-Induced Lower Respiratory Tract Infections

Yingxin Zhao, Mohammad Jamaluddin, Yueqing Zhang, Hong Sun, Teodora Ivanciuc, Roberto P. Garofalo, Allan R. Brasier

J Immunol. Author manuscript; available in PMC 2018 Apr 15.

Published in final edited form as: J Immunol. 2017 Apr 15; 198(8): 3345–3364. Published online 2017 Mar 3. doi: 10.4049/jimmunol.1601291

PMCID:: PMC5380581

Abstract Article PDF–2.6M

Select item 496585815.

Unique proteome signature of post-chemotherapy ovarian cancer ascites-derived tumor cells

Nuzhat Ahmed, David Greening, Chantel Samardzija, Ruth M. Escalona, Maoshan Chen, Jock K. Findlay, George Kannourakis

Sci Rep. 2016; 6: 30061. Published online 2016 Jul 29. doi: 10.1038/srep30061

PMCID:: PMC4965858

Abstract Article PDF–1.1M

Select item 471821116.

The Concise Guide to PHARMACOLOGY 2015/16: Enzymes

Stephen PH Alexander, Doriano Fabbro, Eamonn Kelly, Neil Marrion, John A Peters, Helen E Benson, Elena Faccenda, Adam J Pawson, Joanna L Sharman, Christopher Southan, Jamie A Davies, CGTP Collaborators

Br J Pharmacol. 2015 Dec; 172(24): 6024–6109. Published online 2015 Dec 9. doi: 10.1111/bph.13354

PMCID:: PMC4718211

Abstract Article PDF–2.0M

Select item 405761817.

A framework for application of metabolic modeling in yeast to predict the effects of nsSNV in human orthologs

Hayley Dingerdissen, Daniel S Weaver, Peter D Karp, Yang Pan, Vahan Simonyan, Raja Mazumder

Biol Direct. 2014; 9: 9. Published online 2014 Jun 3. doi: 10.1186/1745-6150-9-9

PMCID:: PMC4057618

Abstract Article PDF–2.4M

Select item 391267818.

A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway

Alexander Mazein, Steven Watterson, Wei-Yuan Hsieh, William J. Griffiths, Peter Ghazal

Biochem Pharmacol. 2013 Jul 1; 86(1): 56–66. doi: 10.1016/j.bcp.2013.03.021

PMCID:: PMC3912678

Abstract Article

Select item 389229319.

The Concise Guide to Pharmacology 2013/14: Enzymes

Stephen PH Alexander, Helen E Benson, Elena Faccenda, Adam J Pawson, Joanna L Sharman, Michael Spedding, John A Peters, Anthony J Harmar

Br J Pharmacol. 2013 Dec; 170(8): 1797–1867. Published online 2013 Dec 17. doi: 10.1111/bph.12451

PMCID:: PMC3892293

Abstract Article PDF–1.6M

Select item 367919320.

Role of the Retinal Vascular Endothelial Cell in Ocular Disease

Arpita S. Bharadwaj, Binoy Appukuttan, Phillip A. Wilmarth, Yuzhen Pan, Andrew J. Stempel, Timothy J. Chipps, Eric E. Benedetti, David O. Zamora, Dongseok Choi, Larry L. David, Justine R. Smith

Prog Retin Eye Res. Author manuscript; available in PMC 2014 Jan 1.

Published in final edited form as: Prog Retin Eye Res. 2013 Jan; 32: 102–180. Published online 2012 Sep 11. doi: 10.1016/j.preteyeres.2012.08.004