RecName: Full=DNA repair nuclease/redox regulator APEX1; AltName: Full - Protein

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APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy. [Cell Death Differ. 2024]
APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy.
Du Y, Zhou Y, Yan X, Pan F, He L, Guo Z, Hu Z. Cell Death Differ. 2024 Apr; 31(4):431-446. Epub 2024 Feb 28.
Back-Up Base Excision DNA Repair in Human Cells Deficient in the Major AP Endonuclease, APE1. [Int J Mol Sci. 2023]
Back-Up Base Excision DNA Repair in Human Cells Deficient in the Major AP Endonuclease, APE1.
Kim DV, Diatlova EA, Zharkov TD, Melentyev VS, Yudkina AV, Endutkin AV, Zharkov DO. Int J Mol Sci. 2023 Dec 20; 25(1). Epub 2023 Dec 20.
In vitro and In vivo evidence demonstrating chronic absence of Ref-1 Cysteine 65 impacts Ref-1 folding configuration, redox signaling, proliferation and metastasis in pancreatic cancer. [Redox Biol. 2024]
In vitro and In vivo evidence demonstrating chronic absence of Ref-1 Cysteine 65 impacts Ref-1 folding configuration, redox signaling, proliferation and metastasis in pancreatic cancer.
Mijit M, Kpenu E, Chowdhury NN, Gampala S, Wireman R, Liu S, Babb O, Georgiadis MM, Wan J, Fishel ML, et al. Redox Biol. 2024 Feb; 69:102977. Epub 2023 Dec 1.

RefSeq genomic sequence
See the genomic reference sequence for the APEX1 gene (NG_008718.1).
RefSeq protein isoforms
See 4 reference sequence protein isoforms for the APEX1 gene.

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P27695 [Domain Mapping of Disease Mut...]
P27695
Domain Mapping of Disease Mutations
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF)
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
Reactome [Reactome]
Reactome
reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome
Evolutionary Trace of Functional Site [Evolutionary Trace of Functio...]
Evolutionary Trace of Functional Site

RecName: Full=DNA repair nuclease/redox regulator APEX1; AltName: Full=APEX nucl...
RecName: Full=DNA repair nuclease/redox regulator APEX1; AltName: Full=APEX nuclease; Short=APEN; AltName: Full=Apurinic-apyrimidinic endonuclease 1; Short=AP endonuclease 1; Short=APE-1; AltName: Full=DNA-(apurinic or apyrimidinic site) endonuclease; AltName: Full=Redox factor-1; Short=REF-1; Contains: RecName: Full=DNA repair nuclease/redox regulator APEX1, mitochondrial
gi|113984|sp|P27695.2|APEX1_HUMAN

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