RecName: Full=Ras GTPase-activating-like protein IQGAP1; AltName: Full - Protein

Run BLAST
Find regions of similarity between this sequence and other sequences using BLAST.
Identify Conserved Domains
View conserved domains detected in this protein sequence using CD-search.
Highlight Sequence Features
Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More...
Find in this Sequence
Finds sub-sequences or patterns in the sequence and highlights the matching regions. The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. More...

In silico predicted compound targeting the IQGAP1-GRD domain selectively inhibits growth of human acute myeloid leukemia. [Sci Rep. 2024]
In silico predicted compound targeting the IQGAP1-GRD domain selectively inhibits growth of human acute myeloid leukemia.
Sahasrabudhe DM, Liesveld JL, Minhajuddin M, Singh NA, Nath S, Kumar VM, Balys M, Evans AG, Azadniv M, Hansen JN, et al. Sci Rep. 2024 Jun 4; 14(1):12868. Epub 2024 Jun 4.
Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein. [J Cell Biol. 2024]
Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein.
Pimm ML, Haarer BK, Nobles AD, Haney LM, Marcin AG, Alcaide Eligio M, Henty-Ridilla JL. J Cell Biol. 2024 Sep 2; 223(9). Epub 2024 May 24.
IQGAP1 promotes mitochondrial damage and activation of the mtDNA sensor cGAS-STING pathway to induce endothelial cell pyroptosis leading to atherosclerosis. [Int Immunopharmacol. 2023]
IQGAP1 promotes mitochondrial damage and activation of the mtDNA sensor cGAS-STING pathway to induce endothelial cell pyroptosis leading to atherosclerosis.
An C, Sun F, Liu C, Huang S, Xu T, Zhang C, Ge S. Int Immunopharmacol. 2023 Oct; 123:110795. Epub 2023 Aug 17.

RefSeq protein isoforms
See 3 reference sequence protein isoforms for the IQGAP1 gene.

PubMed
PubMed articles cited by protein sequence record
Taxonomy
Taxonomy sequences associated with protein record
BioAssay by Target (Summary)
BioAssay by Target (Summary)
BioSystems
BioSystems
CDD Search Results
Display conserved domains within a protein
Conserved Domains (Concise)
Link to a concise list of conserved domains in a protein
Conserved Domains (Full)
Link to conserved domains within a protein
Domain Relatives
Display proteins with similar conserved domain architecture
Full text in PMC
Free full text articles in PMC
Gene
Link to related Genes
Identical Structures
3D structures for identical protein sequences
OMIM
OMIM records associated with protein sequence
Protein (RefSeq)
Protein gi (UniProtKB) to protein gi (refseq)
PubMed (Weighted)
Links to pubmed
Related Structures (List)
List of related structures

P46940 [Domain Mapping of Disease Mut...]
P46940
Domain Mapping of Disease Mutations
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF)
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
Reactome [Reactome]
Reactome
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome
reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome

RecName: Full=Ras GTPase-activating-like protein IQGAP1; AltName: Full=p195
RecName: Full=Ras GTPase-activating-like protein IQGAP1; AltName: Full=p195
gi|1170586|sp|P46940.1|IQGA1_HUMAN

Protein

Your browsing activity is empty.

Activity recording is turned off.

Protein