RecName: Full=Bifunctional 3'-5' exonuclease/ATP-dependent helicase WR - Protein

Run BLAST
Find regions of similarity between this sequence and other sequences using BLAST.
Identify Conserved Domains
View conserved domains detected in this protein sequence using CD-search.
Highlight Sequence Features
Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More...
Find in this Sequence
Finds sub-sequences or patterns in the sequence and highlights the matching regions. The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. More...

WRN exonuclease imparts high fidelity on translesion synthesis by Y family DNA polymerases. [Genes Dev. 2024]
WRN exonuclease imparts high fidelity on translesion synthesis by Y family DNA polymerases.
Yoon JH, Sellamuthu K, Prakash L, Prakash S. Genes Dev. 2024 Apr 17; 38(5-6):213-232. Epub 2024 Apr 17.
Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR. [Genes Dev. 2023]
Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR.
Zong D, Koussa NC, Cornwell JA, Pankajam AV, Kruhlak MJ, Wong N, Chari R, Cappell SD, Nussenzweig A. Genes Dev. 2023 Oct 1; 37(19-20):913-928. Epub 2023 Nov 6.
Werner syndrome protein works as a dimer for unwinding and replication fork regression. [Nucleic Acids Res. 2023]
Werner syndrome protein works as a dimer for unwinding and replication fork regression.
Shin S, Hyun K, Lee J, Joo D, Kulikowicz T, Bohr VA, Kim J, Hohng S. Nucleic Acids Res. 2023 Jan 11; 51(1):337-348.

RefSeq genomic sequence
See the genomic reference sequence for the WRN gene (NG_008870.1).
RefSeq protein isoforms
See 5 reference sequence protein isoforms for the WRN gene.

PubMed
PubMed articles cited by protein sequence record
Taxonomy
Taxonomy sequences associated with protein record
BioAssay by Target (Summary)
BioAssay by Target (Summary)
BioSystems
BioSystems
CDD Search Results
Display conserved domains within a protein
Conserved Domains (Concise)
Link to a concise list of conserved domains in a protein
Conserved Domains (Full)
Link to conserved domains within a protein
Domain Relatives
Display proteins with similar conserved domain architecture
Full text in PMC
Free full text articles in PMC
Gene
Link to related Genes
Identical Structures
3D structures for identical protein sequences
OMIM
OMIM records associated with protein sequence
Protein (RefSeq)
Protein gi (UniProtKB) to protein gi (refseq)
PubMed (Weighted)
Links to pubmed
Related Structures (List)
List of related structures

Q14191 [Domain Mapping of Disease Mut...]
Q14191
Domain Mapping of Disease Mutations
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
Reactome [Reactome]
Reactome
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome
reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome

RecName: Full=Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN; AltName...
RecName: Full=Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN; AltName: Full=DNA helicase, RecQ-like type 3; AltName: Full=RecQ protein-like 2; AltName: Full=Werner syndrome protein; Includes: RecName: Full=3'-5' exonuclease; Includes: RecName: Full=ATP-dependent helicase; AltName: Full=DNA 3'-5' helicase WRN
gi|322510082|sp|Q14191.2|WRN_HUMAN

Protein

Your browsing activity is empty.

Activity recording is turned off.

Protein