RecName: Full=Hepatocyte nuclear factor 1-beta; Short=HNF-1-beta; Shor - Protein

Change region shown

Customize view

Analyze this sequence

Run BLAST
Find regions of similarity between this sequence and other sequences using BLAST.
Identify Conserved Domains
View conserved domains detected in this protein sequence using CD-search.
Highlight Sequence Features
Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More...
Find in this Sequence
Finds sub-sequences or patterns in the sequence and highlights the matching regions. The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. More...

Protein 3D Structure

Hepatocyte Nuclear Factor 1b bound to DNA: MODY5 Gene Product

PDB: 2H8R

Source: Homo sapiens, synthetic construct

Method: X-ray Diffraction

Resolution: 3.2 Å

See all 2 structures...

Articles about the HNF1B gene

Human pluripotent stem cell-derived kidney organoids reveal tubular epithelial pathobiology of heterozygous HNF1B-associated dysplastic kidney malformations. [Stem Cell Reports. 2024]
Human pluripotent stem cell-derived kidney organoids reveal tubular epithelial pathobiology of heterozygous HNF1B-associated dysplastic kidney malformations.
Bantounas I, Rooney KM, Lopes FM, Tengku F, Woods S, Zeef LAH, Lin IH, Kuba SY, Bates N, Hummelgaard S, et al. Stem Cell Reports. 2024 Jun 11; 19(6):859-876. Epub 2024 May 23.
Prenatal diagnosis and perinatal findings of 17q12 microdeletion encompassing HNF1B in a fetus with bilateral hyperechogenic kidneys on fetal ultrasound and mild renal abnormality after birth, and a review of the literature of prenatal diagnosis of 17q12 microdeletion. [Taiwan J Obstet Gynecol. 2024]
Prenatal diagnosis and perinatal findings of 17q12 microdeletion encompassing HNF1B in a fetus with bilateral hyperechogenic kidneys on fetal ultrasound and mild renal abnormality after birth, and a review of the literature of prenatal diagnosis of 17q12 microdeletion.
Chen CP, Wu FT, Pan YT, Wu PS, Wang W. Taiwan J Obstet Gynecol. 2024 Jan; 63(1):77-80.
Hepatocyte nuclear factor 1B deletion, but not intragenic mutation, might be more susceptible to hypomagnesemia. [J Diabetes Investig. 2024]
Hepatocyte nuclear factor 1B deletion, but not intragenic mutation, might be more susceptible to hypomagnesemia.
Wang Y, Xiao X, Lin Q, Song R, Wang X, Liang Y, Chen J, Luan X, Zhou Z, Xiao Y, et al. J Diabetes Investig. 2024 Jan; 15(1):121-130. Epub 2023 Sep 22.

See all...

Reference sequence information

RefSeq genomic sequence
See the genomic reference sequence for the HNF1B gene (NG_013019.2).
RefSeq protein isoforms
See 23 reference sequence protein isoforms for the HNF1B gene.

More about the HNF1B gene

This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodime...
Also Known As: ADTKD3, FJHN, HNF-1-bet...

Related information

PubMed
PubMed articles cited by protein sequence record
Taxonomy
Taxonomy sequences associated with protein record
BioSystems
BioSystems
CDD Search Results
Display conserved domains within a protein
Conserved Domains (Concise)
Link to a concise list of conserved domains in a protein
Conserved Domains (Full)
Link to conserved domains within a protein
Domain Relatives
Display proteins with similar conserved domain architecture
Full text in PMC
Free full text articles in PMC
Gene
Link to related Genes
Identical Structures
3D structures for identical protein sequences
OMIM
OMIM records associated with protein sequence
Protein (RefSeq)
Protein gi (UniProtKB) to protein gi (refseq)
PubMed (Weighted)
Links to pubmed
Related Structures (List)
List of related structures

LinkOut to external resources

P35680 [Domain Mapping of Disease Mut...]
P35680
Domain Mapping of Disease Mutations
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF)
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
Reactome [Reactome]
Reactome
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome
reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome

Recent activity

Clear Turn Off Turn On

RecName: Full=Hepatocyte nuclear factor 1-beta; Short=HNF-1-beta; Short=HNF-1B; ...
RecName: Full=Hepatocyte nuclear factor 1-beta; Short=HNF-1-beta; Short=HNF-1B; AltName: Full=Homeoprotein LFB3; AltName: Full=Transcription factor 2; Short=TCF-2; AltName: Full=Variant hepatic nuclear factor 1; Short=vHNF1
gi|547664|sp|P35680.1|HNF1B_HUMAN

Protein

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

Protein

Result Filters

Send to:

RecName: Full=Hepatocyte nuclear factor 1-beta; Short=HNF-1-beta; Short=HNF-1B; AltName: Full=Homeoprotein LFB3; AltName: Full=Transcription factor 2; Short=TCF-2; AltName: Full=Variant hepatic nuclear factor 1; Short=vHNF1

Supplemental Content

Change region shown

Customize view

Features added by NCBI

Analyze this sequence

Protein 3D Structure

Articles about the HNF1B gene

Reference sequence information

More about the HNF1B gene

Related information

LinkOut to external resources

Recent activity