RecName: Full=Potassium voltage-gated channel subfamily KQT member 1; - Protein

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Protein 3D Structure

Solution NMR structure of the KCNQ1 voltage-sensing domain

PDB: 6MIE

Source: Homo sapiens

Method: Solution NMR

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Articles about the KCNQ1 gene

KCNQ1 p.D446E Variant as a Risk Allele for Arrhythmogenic Phenotypes: Electrophysiological Characterization Reveals a Complex Phenotype Affecting the Slow Delayed Rectifier Potassium Current (IKs) Voltage Dependence by Causing a Hyperpolarizing Shift and a Lack of Response to Protein Kinase A Activation. [Int J Mol Sci. 2024]
KCNQ1 p.D446E Variant as a Risk Allele for Arrhythmogenic Phenotypes: Electrophysiological Characterization Reveals a Complex Phenotype Affecting the Slow Delayed Rectifier Potassium Current (IKs) Voltage Dependence by Causing a Hyperpolarizing Shift and a Lack of Response to Protein Kinase A Activation.
González-Garrido A, López-Ramírez O, Cerda-Mireles A, Navarrete-Miranda T, Flores-Arenas AI, Rojo-Domínguez A, Arregui L, Iturralde P, Antúnez-Argüelles E, Domínguez-Pérez M, et al. Int J Mol Sci. 2024 Jan 12; 25(2). Epub 2024 Jan 12.
Novel combinations of variations in KCNQ1 were associated with patients with long QT syndrome or Jervell and Lange-Nielsen syndrome. [BMC Cardiovasc Disord. 2023]
Novel combinations of variations in KCNQ1 were associated with patients with long QT syndrome or Jervell and Lange-Nielsen syndrome.
Zhao N, Yu Z, Cai Z, Chen W, He X, Huo Z, Lin X. BMC Cardiovasc Disord. 2023 Aug 12; 23(1):399. Epub 2023 Aug 12.
The role of native cysteine residues in the oligomerization of KCNQ1 channels. [Biochem Biophys Res Commun. 2023]
The role of native cysteine residues in the oligomerization of KCNQ1 channels.
Bates A, Stowe RB, Travis EM, Cook LE, Dabney-Smith C, Lorigan GA. Biochem Biophys Res Commun. 2023 Jun 4; 659:34-39. Epub 2023 Mar 31.

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Reference sequence information

RefSeq genomic sequence
See the genomic reference sequence for the KCNQ1 gene (NG_008935.1).
RefSeq protein isoforms
See 6 reference sequence protein isoforms for the KCNQ1 gene.

More about the KCNQ1 gene

This gene encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form...
Also Known As: ATFB1, ATFB3, JLNS1, KC...

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MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF)
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RecName: Full=Potassium voltage-gated channel subfamily KQT member 1; AltName: F...
RecName: Full=Potassium voltage-gated channel subfamily KQT member 1; AltName: Full=IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; AltName: Full=KQT-like 1; AltName: Full=Voltage-gated potassium channel subunit Kv7.1
gi|6166005|sp|P51787.3|KCNQ1_HUMAN

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RecName: Full=Potassium voltage-gated channel subfamily KQT member 1; AltName: Full=IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; AltName: Full=KQT-like 1; AltName: Full=Voltage-gated potassium channel subunit Kv7.1

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