RecName: Full=Beta-secretase 2; AltName: Full=Aspartic-like protease 5 - Protein

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m(6)A RNA hypermethylation-induced BACE2 boosts intracellular calcium release and accelerates tumorigenesis of ocular melanoma. [Mol Ther. 2021]
m(6)A RNA hypermethylation-induced BACE2 boosts intracellular calcium release and accelerates tumorigenesis of ocular melanoma.
He F, Yu J, Yang J, Wang S, Zhuang A, Shi H, Gu X, Xu X, Chai P, Jia R. Mol Ther. 2021 Jun 2; 29(6):2121-2133. Epub 2021 Feb 15.
Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain. [Mol Psychiatry. 2021]
Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain.
Alić I, Goh PA, Murray A, Portelius E, Gkanatsiou E, Gough G, Mok KY, Koschut D, Brunmeir R, Yeap YJ, et al. Version 2. Mol Psychiatry. 2021 Oct; 26(10):5766-5788. Epub 2020 Jul 10.
BACE2 degradation is mediated by both the proteasome and lysosome pathways. [BMC Mol Cell Biol. 2020]
BACE2 degradation is mediated by both the proteasome and lysosome pathways.
Qiu K, Liang W, Wang S, Kong T, Wang X, Li C, Wang Z, Wu Y. BMC Mol Cell Biol. 2020 Mar 11; 21(1):13. Epub 2020 Mar 11.

RefSeq protein isoforms
See 6 reference sequence protein isoforms for the BACE2 gene.

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Q9Y5Z0 [Domain Mapping of Disease Mut...]
Q9Y5Z0
Domain Mapping of Disease Mutations
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF)
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome
reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome
Evolutionary Trace of Functional Site [Evolutionary Trace of Functio...]
Evolutionary Trace of Functional Site

RecName: Full=Beta-secretase 2; AltName: Full=Aspartic-like protease 56 kDa; Alt...
RecName: Full=Beta-secretase 2; AltName: Full=Aspartic-like protease 56 kDa; AltName: Full=Aspartyl protease 1; Short=ASP1; Short=Asp 1; AltName: Full=Beta-site amyloid precursor protein cleaving enzyme 2; Short=Beta-site APP cleaving enzyme 2; AltName: Full=Down region aspartic protease; Short=DRAP; AltName: Full=Memapsin-1; AltName: Full=Membrane-associated aspartic protease 1; AltName: Full=Theta-secretase; Flags: Precursor
gi|6685260|sp|Q9Y5Z0.1|BACE2_HUMAN

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