RecName: Full=Splicing regulator SDE2; AltName: Full=Replication stres - Protein

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Extended DNA-binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks. [J Biol Chem. 2022]
Extended DNA-binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks.
Weinheimer AS, Paung Y, Rageul J, Khan A, Lo N, Ho B, Tong M, Alphonse S, Seeliger MA, Kim H. J Biol Chem. 2022 Aug; 298(8):102268. Epub 2022 Jul 16.
SDE2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing. [Nucleic Acids Res. 2021]
SDE2 is an essential gene required for ribosome biogenesis and the regulation of alternative splicing.
Floro J, Dai A, Metzger A, Mora-Martin A, Ganem NJ, Cifuentes D, Wu CS, Dalal J, Lyons SM, Labadorf A, et al. Nucleic Acids Res. 2021 Sep 20; 49(16):9424-9443.
SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks. [Nat Commun. 2020]
SDE2 integrates into the TIMELESS-TIPIN complex to protect stalled replication forks.
Rageul J, Park JJ, Zeng PP, Lee EA, Yang J, Hwang S, Lo N, Weinheimer AS, Schärer OD, Yeo JE, et al. Nat Commun. 2020 Oct 30; 11(1):5495. Epub 2020 Oct 30.

RefSeq protein
See the reference protein sequence for splicing regulator SDE2 (NP_689821.3).

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Q6IQ49 [Domain Mapping of Disease Mut...]
Q6IQ49
Domain Mapping of Disease Mutations
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RecName: Full=Splicing regulator SDE2; AltName: Full=Replication stress response...
RecName: Full=Splicing regulator SDE2; AltName: Full=Replication stress response regulator SDE2; Flags: Precursor
gi|74748828|sp|Q6IQ49.1|SDE2_HUMAN

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