RecName: Full=High affinity nerve growth factor receptor; AltName: Ful - Protein

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Protein 3D Structure

TRK-A IN COMPLEX WITH LIGAND 1

PDB: 6PL4

Source: Homo sapiens

Method: X-ray Diffraction

Resolution: 2.06 Å

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Articles about the NTRK1 gene

A recurrent NTRK1 tyrosine kinase domain mutation pair is characteristic in a subset of dedifferentiated liposarcomas. [Eur J Cancer. 2024]
A recurrent NTRK1 tyrosine kinase domain mutation pair is characteristic in a subset of dedifferentiated liposarcomas.
Lippai Z, Péterfia B, Papp G, Dezső K, Bedics G, Pápai Z, Lamers MH, Kuin RC, Szuhai K, Sápi Z. Eur J Cancer. 2024 May; 202:114005. Epub 2024 Mar 14.
Pan-TRK immunohistochemistry in gynaecological mesenchymal tumours: diagnostic implications and pitfalls. [Histopathology. 2024]
Pan-TRK immunohistochemistry in gynaecological mesenchymal tumours: diagnostic implications and pitfalls.
Moura MS, Costa J, Velasco V, Kommoss F, Oliva E, Le Loarer F, McCluggage WG, Razack R, Treilleux I, Mills A, et al. Histopathology. 2024 Feb; 84(3):451-462. Epub 2023 Nov 21.
Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors. [Int J Clin Oncol. 2023]
Japanese Society of Medical Oncology/Japan Society of Clinical Oncology/Japanese Society of Pediatric Hematology/Oncology-led clinical recommendations on the diagnosis and use of tropomyosin receptor kinase inhibitors in adult and pediatric patients with neurotrophic receptor tyrosine kinase fusion-positive advanced solid tumors.
Naito Y, Mishima S, Akagi K, Hayashi N, Hirasawa A, Hishiki T, Igarashi A, Ikeda M, Kadowaki S, Kajiyama H, et al. Int J Clin Oncol. 2023 Jul; 28(7):827-840. Epub 2023 May 22.

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Reference sequence information

RefSeq genomic sequence
See the genomic reference sequence for the NTRK1 gene (NG_007493.1).
RefSeq protein isoforms
See 3 reference sequence protein isoforms for the NTRK1 gene.

More about the NTRK1 gene

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon n...
Also Known As: MTC, TRK, TRK1, TRKA, T...

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P04629 [Domain Mapping of Disease Mut...]
P04629
Domain Mapping of Disease Mutations
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
Reactome [Reactome]
Reactome
reagents [ExactAntigen/Labome]
reagents
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reagent reviews [ExactAntigen/Labome]
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ExactAntigen/Labome

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RecName: Full=High affinity nerve growth factor receptor; AltName: Full=Neurotro...
RecName: Full=High affinity nerve growth factor receptor; AltName: Full=Neurotrophic tyrosine kinase receptor type 1; AltName: Full=TRK1-transforming tyrosine kinase protein; AltName: Full=Tropomyosin-related kinase A; AltName: Full=Tyrosine kinase receptor; AltName: Full=Tyrosine kinase receptor A; Short=Trk-A; AltName: Full=gp140trk; AltName: Full=p140-TrkA; Flags: Precursor
gi|94730402|sp|P04629.4|NTRK1_HUMAN

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RecName: Full=High affinity nerve growth factor receptor; AltName: Full=Neurotrophic tyrosine kinase receptor type 1; AltName: Full=TRK1-transforming tyrosine kinase protein; AltName: Full=Tropomyosin-related kinase A; AltName: Full=Tyrosine kinase receptor; A...

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