IQ motif containing GTPase activating protein 1 [Homo sapiens]

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In silico predicted compound targeting the IQGAP1-GRD domain selectively inhibits growth of human acute myeloid leukemia. [Sci Rep. 2024]
In silico predicted compound targeting the IQGAP1-GRD domain selectively inhibits growth of human acute myeloid leukemia.
Sahasrabudhe DM, Liesveld JL, Minhajuddin M, Singh NA, Nath S, Kumar VM, Balys M, Evans AG, Azadniv M, Hansen JN, et al. Sci Rep. 2024 Jun 4; 14(1):12868. Epub 2024 Jun 4.
Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein. [J Cell Biol. 2024]
Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein.
Pimm ML, Haarer BK, Nobles AD, Haney LM, Marcin AG, Alcaide Eligio M, Henty-Ridilla JL. J Cell Biol. 2024 Sep 2; 223(9). Epub 2024 May 24.
IQGAP1 promotes mitochondrial damage and activation of the mtDNA sensor cGAS-STING pathway to induce endothelial cell pyroptosis leading to atherosclerosis. [Int Immunopharmacol. 2023]
IQGAP1 promotes mitochondrial damage and activation of the mtDNA sensor cGAS-STING pathway to induce endothelial cell pyroptosis leading to atherosclerosis.
An C, Sun F, Liu C, Huang S, Xu T, Zhang C, Ge S. Int Immunopharmacol. 2023 Oct; 123:110795. Epub 2023 Aug 17.

RefSeq genomic sequence
See the genomic reference sequence for the IQGAP1 gene (NG_052946.1).
RefSeq protein isoforms
See 3 reference sequence protein isoforms for the IQGAP1 gene.

Nucleotide
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Protein