hypoxanthine-guanine phosphoribosyltransferase [Homo sapiens]

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Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas. [Nat Commun. 2023]
Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas.
Yin J, Wang X, Ge X, Ding F, Shi Z, Ge Z, Huang G, Zhao N, Chen D, Zhang J, et al. Nat Commun. 2023 Sep 22; 14(1):5913. Epub 2023 Sep 22.
Hypoxanthine-guanine phosphoribosyltransferase is activated via positive cooperativity between guanine and IMP. [FEBS Lett. 2022]
Hypoxanthine-guanine phosphoribosyltransferase is activated via positive cooperativity between guanine and IMP.
Ueda S, Hirata T, Sakasegawa SI. FEBS Lett. 2022 Apr; 596(8):1072-1080. Epub 2022 Feb 10.
Overexpression of HPRT1 is associated with poor prognosis in head and neck squamous cell carcinoma. [FEBS Open Bio. 2021]
Overexpression of HPRT1 is associated with poor prognosis in head and neck squamous cell carcinoma.
Ahmadi M, Eftekhari Kenzerki M, Akrami SM, Pashangzadeh S, Hajiesmaeili F, Rahnavard S, Habibipour L, Saffarzadeh N, Mousavi P. FEBS Open Bio. 2021 Sep; 11(9):2525-2540. Epub 2021 Aug 4.

RefSeq genomic sequence
See the genomic reference sequence for the HPRT1 gene (NG_012329.2).
RefSeq mRNA
See reference mRNA sequence for the HPRT1 gene (NM_000194.3).

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NP_000185 [Domain Mapping of Disease Mut...]
NP_000185
Domain Mapping of Disease Mutations
Ensembl [Ensembl]
Ensembl
GlyGen glycoinformatics resource [GlyGen glycoinformatics resou...]
GlyGen glycoinformatics resource
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF)
OncoMX cancer biomarker resource [OncoMX cancer biomarker resou...]
OncoMX cancer biomarker resource
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
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reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome
Find Quality Antibodies [GeneTex Inc]
Find Quality Antibodies
GeneTex Inc
Evolutionary Trace of Functional Site [Evolutionary Trace of Functio...]
Evolutionary Trace of Functional Site

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