DNA-dependent metalloprotease SPRTN isoform c [Homo sapiens]

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SPRTN is involved in hepatocellular carcinoma development through the ER stress response. [Cancer Gene Ther. 2024]
SPRTN is involved in hepatocellular carcinoma development through the ER stress response.
Batel A, Polović M, Glumac M, Šuman O, Jadrijević S, Lozić B, Petrović M, Samardžija B, Bradshaw NJ, Skube K, et al. Cancer Gene Ther. 2024 Mar; 31(3):376-386. Epub 2023 Dec 12.
SPRTN patient variants cause global-genome DNA-protein crosslink repair defects. [Nat Commun. 2023]
SPRTN patient variants cause global-genome DNA-protein crosslink repair defects.
Weickert P, Li HY, Götz MJ, Dürauer S, Yaneva D, Zhao S, Cordes J, Acampora AC, Forne I, Imhof A, et al. Nat Commun. 2023 Jan 21; 14(1):352. Epub 2023 Jan 21.
The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability. [Cell Rep. 2021]
The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability.
Ruggiano A, Vaz B, Kilgas S, Popović M, Rodriguez-Berriguete G, Singh AN, Higgins GS, Kiltie AE, Ramadan K. Cell Rep. 2021 Dec 7; 37(10):110080.

RefSeq genomic sequence
See the genomic reference sequence for the SPRTN gene (NG_042052.1).
RefSeq mRNA
See reference mRNA sequence for the SPRTN gene (NM_001261462.3).
RefSeq protein isoforms
See 5 reference sequence protein isoforms for the SPRTN gene.

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NP_001248391 [Domain Mapping of Disease Mut...]
NP_001248391
Domain Mapping of Disease Mutations
Ensembl [Ensembl]
Ensembl
OncoMX cancer biomarker resource [OncoMX cancer biomarker resou...]
OncoMX cancer biomarker resource
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reagents [ExactAntigen/Labome]
reagents
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MULTISPECIES: OmpA family protein [Bacillaceae]
MULTISPECIES: OmpA family protein [Bacillaceae]
gi|1207716685|ref|WP_088074042.1|

Protein
DNA-dependent metalloprotease SPRTN isoform a [Homo sapiens]
DNA-dependent metalloprotease SPRTN isoform a [Homo sapiens]
gi|58331105|ref|NP_114407.3|

Protein
PREDICTED: Nelumbo nucifera protein furry homolog-like (LOC104608078), transcrip...
PREDICTED: Nelumbo nucifera protein furry homolog-like (LOC104608078), transcript variant X1, mRNA
gi|1102779326|ref|XM_010273943.2|

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