RecName: Full=Histidine--tRNA ligase, cytoplasmic; AltName: Full=Histi - Protein

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Bi-allelic mutations in HARS1 severely impair histidyl-tRNA synthetase expression and enzymatic activity causing a novel multisystem ataxic syndrome. [Hum Mutat. 2020]
Bi-allelic mutations in HARS1 severely impair histidyl-tRNA synthetase expression and enzymatic activity causing a novel multisystem ataxic syndrome.
Galatolo D, Kuo ME, Mullen P, Meyer-Schuman R, Doccini S, Battini R, Lieto M, Tessa A, Filla A, Francklyn C, et al. Hum Mutat. 2020 Jul; 41(7):1232-1237. Epub 2020 Apr 29.
Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses. [Cell Mol Immunol. 2021]
Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses.
Adams RA, Fernandes-Cerqueira C, Notarnicola A, Mertsching E, Xu Z, Lo WS, Ogilvie K, Chiang KP, Ampudia J, Rosengren S, et al. Cell Mol Immunol. 2021 Jun; 18(6):1463-1475. Epub 2019 Dec 4.
The Usher Syndrome Type IIIB Histidyl-tRNA Synthetase Mutation Confers Temperature Sensitivity. [Biochemistry. 2017]
The Usher Syndrome Type IIIB Histidyl-tRNA Synthetase Mutation Confers Temperature Sensitivity.
Abbott JA, Guth E, Kim C, Regan C, Siu VM, Rupar CA, Demeler B, Francklyn CS, Robey-Bond SM. Biochemistry. 2017 Jul 18; 56(28):3619-3631. Epub 2017 Jul 7.

RefSeq genomic sequence
See the genomic reference sequence for the HARS1 gene (NG_032158.1).
RefSeq protein isoforms
See 7 reference sequence protein isoforms for the HARS1 gene.

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P12081 [Domain Mapping of Disease Mut...]
P12081
Domain Mapping of Disease Mutations
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF)
Transcript/Protein Information [PANTHER Classification System]
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Reactome
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reagents
ExactAntigen/Labome

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