RecName: Full=tRNA N(3)-methylcytidine methyltransferase METTL8, mitoc - Protein

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METTL8 links mt-tRNA m(3)C modification to the HIF1α/RTK/Akt axis to sustain GBM stemness and tumorigenicity. [Cell Death Dis. 2024]
METTL8 links mt-tRNA m(3)C modification to the HIF1α/RTK/Akt axis to sustain GBM stemness and tumorigenicity.
Lee BWL, Chuah YH, Yoon J, Grinchuk OV, Liang Y, Hirpara JL, Shen Y, Wang LC, Lim YT, Zhao T, et al. Cell Death Dis. 2024 May 14; 15(5):338. Epub 2024 May 14.
Molecular basis for human mitochondrial tRNA m3C modification by alternatively spliced METTL8. [Nucleic Acids Res. 2022]
Molecular basis for human mitochondrial tRNA m3C modification by alternatively spliced METTL8.
Huang MH, Peng GX, Mao XL, Wang JT, Zhou JB, Zhang JH, Chen M, Wang ED, Zhou XL. Nucleic Acids Res. 2022 Apr 22; 50(7):4012-4028.
Methyltransferase METTL8 is required for 3-methylcytosine modification in human mitochondrial tRNAs. [J Biol Chem. 2022]
Methyltransferase METTL8 is required for 3-methylcytosine modification in human mitochondrial tRNAs.
Lentini JM, Bargabos R, Chen C, Fu D. J Biol Chem. 2022 Apr; 298(4):101788. Epub 2022 Mar 3.

RefSeq protein isoforms
See 10 reference sequence protein isoforms for the METTL8 gene.

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Protein