Probing the correlation between ligand efficacy and conformational diversity at the α(1A)-adrenoreceptor reveals allosteric coupling of its microswitches.
Wu FJ, Williams LM, Abdul-Ridha A, Gunatilaka A, Vaid TM, Kocan M, Whitehead AR, Griffin MDW, Bathgate RAD, Scott DJ, et al. J Biol Chem. 2020 May 22; 295(21):7404-7417. Epub 2020 Apr 17.