RecName: Full=Hypoxanthine-guanine phosphoribosyltransferase; Short=HG - Protein

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Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas. [Nat Commun. 2023]
Hypoxanthine phosphoribosyl transferase 1 metabolizes temozolomide to activate AMPK for driving chemoresistance of glioblastomas.
Yin J, Wang X, Ge X, Ding F, Shi Z, Ge Z, Huang G, Zhao N, Chen D, Zhang J, et al. Nat Commun. 2023 Sep 22; 14(1):5913. Epub 2023 Sep 22.
Hypoxanthine-guanine phosphoribosyltransferase is activated via positive cooperativity between guanine and IMP. [FEBS Lett. 2022]
Hypoxanthine-guanine phosphoribosyltransferase is activated via positive cooperativity between guanine and IMP.
Ueda S, Hirata T, Sakasegawa SI. FEBS Lett. 2022 Apr; 596(8):1072-1080. Epub 2022 Feb 10.
Overexpression of HPRT1 is associated with poor prognosis in head and neck squamous cell carcinoma. [FEBS Open Bio. 2021]
Overexpression of HPRT1 is associated with poor prognosis in head and neck squamous cell carcinoma.
Ahmadi M, Eftekhari Kenzerki M, Akrami SM, Pashangzadeh S, Hajiesmaeili F, Rahnavard S, Habibipour L, Saffarzadeh N, Mousavi P. FEBS Open Bio. 2021 Sep; 11(9):2525-2540. Epub 2021 Aug 4.

RefSeq genomic sequence
See the genomic reference sequence for the HPRT1 gene (NG_012329.2).
RefSeq protein
See the reference protein sequence for hypoxanthine-guanine phosphoribosyltransferase (NP_000185.1).

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P00492 [Domain Mapping of Disease Mut...]
P00492
Domain Mapping of Disease Mutations
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF)
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
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Reactome
reagent reviews [ExactAntigen/Labome]
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reagents [ExactAntigen/Labome]
reagents
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Evolutionary Trace of Functional Site [Evolutionary Trace of Functio...]
Evolutionary Trace of Functional Site

RecName: Full=Hypoxanthine-guanine phosphoribosyltransferase; Short=HGPRT; Short...
RecName: Full=Hypoxanthine-guanine phosphoribosyltransferase; Short=HGPRT; Short=HGPRTase
gi|123497|sp|P00492.2|HPRT_HUMAN

Protein
Homo sapiens isolate:CHM13
Homo sapiens isolate:CHM13
Homo sapiens isolate:CHM13 RefSeq Genome sequencing and assembly

BioProject
BioProject Links for Protein (Select 2462544750) (1)
BioProject
Taxonomy Links for Protein (Select 2462544744) (1)
Taxonomy
Nucleotide Links for Protein (Select 2462544762) (2)
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Protein