RecName: Full=Liver carboxylesterase 1; AltName: Full=Acyl-coenzyme A: - Protein

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Protein 3D Structure

Liver carboxylesterase 1

PDB: 8EOR

Source: Homo sapiens

Method: Electron Microscopy

Resolution: 2.67 Å

See all 16 structures...

Articles about the CES1 gene

High-Dose Methylphenidate and Carboxylesterase 1 Genetic Variability in Patients With Attention-Deficit/Hyperactivity Disorder: A Case Series. [J Clin Psychopharmacol. 2024]
High-Dose Methylphenidate and Carboxylesterase 1 Genetic Variability in Patients With Attention-Deficit/Hyperactivity Disorder: A Case Series.
Westerkamp AC, Pereira RR, Huitema VR, Kouwert EAM, Matic M, van Schaik RHN, Punt N, Schoevers RA, Touw DJ. J Clin Psychopharmacol. 2024 Jan-Feb 01; 44(1):35-38. Epub 2023 Oct 17.
The Influence of Structural Variants of the CES1 Gene on the Pharmacokinetics of Enalapril, Presumably Due to Linkage Disequilibrium with the Intronic rs2244613. [Genes (Basel). 2022]
The Influence of Structural Variants of the CES1 Gene on the Pharmacokinetics of Enalapril, Presumably Due to Linkage Disequilibrium with the Intronic rs2244613.
Ikonnikova A, Kazakov R, Rodina T, Dmitriev A, Melnikov E, Zasedatelev A, Nasedkina T. Genes (Basel). 2022 Nov 27; 13(12). Epub 2022 Nov 27.
Identification of regulatory variants of carboxylesterase 1 (CES1): A proof-of-concept study for the application of the Allele-Specific Protein Expression (ASPE) assay in identifying cis-acting regulatory genetic polymorphisms. [Proteomics. 2023]
Identification of regulatory variants of carboxylesterase 1 (CES1): A proof-of-concept study for the application of the Allele-Specific Protein Expression (ASPE) assay in identifying cis-acting regulatory genetic polymorphisms.
Her L, Shi J, Wang X, He B, Smith LS, Jiang H, Zhu HJ. Proteomics. 2023 Jan; 23(1):e2200176. Epub 2022 Dec 7.

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Reference sequence information

RefSeq genomic sequence
See the genomic reference sequence for the CES1 gene (NG_012057.1).
RefSeq protein isoforms
See 6 reference sequence protein isoforms for the CES1 gene.

More about the CES1 gene

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterificatio...
Also Known As: ACAT, CE-1, CEH, CES2, ...

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LinkOut to external resources

P23141 [Domain Mapping of Disease Mut...]
P23141
Domain Mapping of Disease Mutations
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF) [MODBASE, Database of Comparat...]
MODBASE, Database of Comparative Protein Structure Models (Sali Lab/UCSF)
Transcript/Protein Information [PANTHER Classification System]
Transcript/Protein Information
PANTHER Classification System
Reactome [Reactome]
Reactome
reagent reviews [ExactAntigen/Labome]
reagent reviews
ExactAntigen/Labome
reagents [ExactAntigen/Labome]
reagents
ExactAntigen/Labome
Evolutionary Trace of Functional Site [Evolutionary Trace of Functio...]
Evolutionary Trace of Functional Site

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RecName: Full=Liver carboxylesterase 1; AltName: Full=Acyl-coenzyme A:cholestero...
RecName: Full=Liver carboxylesterase 1; AltName: Full=Acyl-coenzyme A:cholesterol acyltransferase; Short=ACAT; AltName: Full=Brain carboxylesterase hBr1; AltName: Full=Carboxylesterase 1; Short=CE-1; Short=hCE-1; AltName: Full=Cholesteryl ester hydrolase; Short=CEH; AltName: Full=Cocaine carboxylesterase; AltName: Full=Egasyn; AltName: Full=HMSE; AltName: Full=Methylumbelliferyl-acetate deacetylase 1; AltName: Full=Monocyte/macrophage serine esterase; AltName: Full=Retinyl ester hydrolase; Short=REH; AltName: Full=Serine esterase 1; AltName: Full=Triacylglycerol hydrolase; Short=TGH; Flags: Precursor
gi|119576|sp|P23141.2|EST1_HUMAN

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RecName: Full=Liver carboxylesterase 1; AltName: Full=Acyl-coenzyme A:cholesterol acyltransferase; Short=ACAT; AltName: Full=Brain carboxylesterase hBr1; AltName: Full=Carboxylesterase 1; Short=CE-1; Short=hCE-1; AltName: Full=Cholesteryl ester hydrolase; Shor...

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