Protein Family Models

This HMM describes NusA, or N utilization substance protein A, a bacterial transcription termination factor. It binds to RNA polymerase alpha subunit and promotes termination at certain RNA hairpin structures. It is named for the interaction in E. coli of phage lambda antitermination protein N with the N-utilization substance, consisting of NusA, NusB, NusE (ribosomal protein S10), and nusG. This model represents a region of NusA shared in all bacterial forms, and including an S1 (PF00575) and a KH (PF00013) RNA binding domains. Proteobacterial forms have an additional C-terminal region, not included in this model, with two repeats of a 50-residue domain rich in acidic amino acids.

Gene:

nusA

Date:

2024-05-16

transcription termination/antitermination protein NusA binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA, and participates in both transcription termination and antitermination

Date:

2022-08-18