Protein Family Models for Gene (Select 89500749) - Protein Family Models

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Items: 9

Select item 3913421.

new record, indexing in progress

Family Accession:

Select item 3902712.

new record, indexing in progress

Family Accession:

Select item 3891843.

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Family Accession:

Select item 3506854.

new record, indexing in progress

Family Accession:

Select item 3477185.

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Family Accession:

Select item 3470586.

new record, indexing in progress

Family Accession:

Select item 864597.

aspartate--tRNA ligase family protein

aspartate--tRNA ligase family protein such as aspartate--tRNA ligase that attaches aspartate to the 3' OH group of ribose of its cognate tRNA(Asp) and aspartate--tRNA(Asp/Asn) ligase that aspartylates both tRNA(Asp) and tRNA(Asn)

Date:: 2024-04-10

Family Accession:: 11478785
Method:: Sparcle

Select item 233928.

aspartate--tRNA ligase

Catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes

Gene:: aspS

GO Terms:

Molecular Function:: nucleotide binding (GO:0000166)

Molecular Function:: aminoacyl-tRNA ligase activity (GO:0004812)

Molecular Function:: ATP binding (GO:0005524)

Biological Process:: tRNA aminoacylation for protein translation (GO:0006418)

Molecular Function:: ligase activity (GO:0016874)

Date:: 2021-07-21

Family Accession:: NF001750.0
Method:: HMM

Select item 202799.

aspartate--tRNA ligase

Asparate--tRNA ligases in this family may be discriminating (6.1.1.12) or nondiscriminating (6.1.1.23). In a multiple sequence alignment of representative asparaginyl-tRNA synthetases (asnS), archaeal/eukaryotic type aspartyl-tRNA synthetases (aspS_arch), and bacterial type aspartyl-tRNA synthetases (aspS_bact), there is a striking similarity between asnS and aspS_arch in gap pattern and in sequence, and a striking divergence of aspS_bact. Consequently, a separate model was built for each of the three groups. This HMM, aspS_bact, represents aspartyl-tRNA synthetases from the Bacteria and from mitochondria. In some species, this enzyme aminoacylates tRNA for both Asp and Asn; Asp-tRNA(asn) is subsequently transamidated to Asn-tRNA(asn). This model generates very low scores for the archaeal type of aspS and for asnS; scores between the trusted and noise cutoffs represent fragmentary sequences.