Protein Family Models

This presumed domain contains at least one helix-hairpin-helix motif. This domain is often found in RecD helicases. (from Pfam)

Date:

2024-08-14

This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins. There is a Walker A and Walker B. (from Pfam)

Date:

2024-08-14

This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

Helicase activity for this family has been demonstrated [1] and NTPase activity [2]. This helicase has multiple roles at different stages of viral RNA replication, as dissected by mutational analysis [3]. This family is discussed pages 388-391.. [1]. 8269709. Evolution and taxonomy of positive-strand RNA viruses:. implications of comparative analysis of amino acid sequences.. Koonin EV, Dolja VV;. Crit Rev Biochem Mol Biol 1993;28:375-430.. [2]. 10217401. RNA helicase activity of Semliki Forest virus replicase protein. NSP2.. Gomez de Cedron M, Ehsani N, Mikkola ML, Garcia JA, Kaariainen. L;. FEBS Lett 1999;448:19-22.. [3]. 8057461. ATPase and GTPase activities associated with Semliki Forest. virus nonstructural protein nsP2.. Rikkonen M, Peranen J, Kaariainen L;. J Virol 1994;68:5804-5810.. [4]. 10982322. Helicase and capping enzyme active site mutations in brome. mosaic virus protein 1a cause defects in template recruitment,. negative-strand RNA synthesis, and viral RNA capping.. Ahola T, den Boon JA, Ahlquist P;. J Virol 2000;74:8803-8811. (from Pfam)

Date:

2024-08-14