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BrnA antitoxin family protein
BrnA is family of antitoxins that neutralises the toxin BrnT, Pfam:PF04365. It consists of 3 alpha-helices and a C-terminal ribbon-helix-helix DNA binding domain. As in other toxin-antitoxin systems, BrnA negatively autoregulates the brnTA operon and has higher affinity for the DNA operator when complexed with BrnT. It dimerises with two molecules of its toxin BrnT [1]. [1]. 22334680. Molecular structure and function of the novel BrnT/BrnA. toxin-antitoxin system of Brucella abortus.. Heaton BE, Herrou J, Blackwell AE, Wysocki VH, Crosson S;. J Biol Chem. 2012;287:12098-12110. (from Pfam)
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