This is the ssDNA binding domain of anti-restriction factor ArdC deployed by plasmids and phages in polyvalent proteins related to the BHD domains of XPC/Rad4 and the Tc-38 domain found in kinetoplastid minicircle binding proteins [1,2,3]. The structure of this domain is composed of three alpha-helices and a three-stranded beta-sheet that supports a long and protuberant beta-hairpin [3]. This domain is also found in the N-terminal region of the RP4 TraC1 primase [4], together with the Toprim domain (pfam:PF01751, pfam:PF13362 and pfam:PF13662). [1]. 30396152. Unexpected Evolution of Lesion-Recognition Modules in Eukaryotic. NER and Kinetoplast DNA Dynamics Proteins from Bacterial Mobile. Elements.. Krishnan A, Burroughs AM, Iyer LM, Aravind L;. iScience. 2018;9:192-208.. [2]. 28559295. Polyvalent Proteins, a Pervasive Theme in the Intergenomic. Biological Conflicts of Bacteriophages and Conjugative Elements.. Iyer LM, Burroughs AM, Anand S, de Souza RF, Aravind L;. J Bacteriol. 2017; [Epub ahead of print]. [3]. 32348296. ArdC, a ssDNA-binding protein with a metalloprotease domain,. overpasses the recipient hsdRMS restriction system broadening. conjugation host range.. Gonzalez-Montes L, Del Campo I, Garcillan-Barcia MP, de la Cruz. F, Moncalian G;. PLoS Genet. 2020;16:e1008750.. [4]. 10686096. Antirestriction protein Ard (Type C) encoded by IncW plasmid pSa. has a high similarity to the "protein transport" domain of TraC1. primase of promiscuous plasmid RP4.. Belogurov AA, Delver EP, Agafonova OV, Belogurova NG, Lee LY,. Kado CI;. J Mol Biol. 2000;296:969-977. (from Pfam)
GO Terms:- Molecular Function:
- single-stranded DNA binding (GO:0003697)
- Date:
- 2024-08-14