Protein Family Models

This family consists of the 116kDa V-type ATPase (vacuolar (H+)-ATPases) subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes [1]. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal [1,2]. It has roles in proton transport and assembly of the V-type ATPase complex [1,2]. This subunit is encoded by two homologous gene in yeast VPH1 and STV1 [2]. Mini-review.. [1]. 10224039. Structure and properties of the vacuolar (H+)-ATPases.. Forgac M;. J Biol Chem 1999;274:12951-12954.. [2]. 10340849. Structure and properties of the clathrin-coated vesicle and. yeast vacuolar V-ATPases.. Forgac M;. J Bioenerg Biomembr 1999;31:57-65. (from Pfam)

Date:

2024-08-14

V-type ATP synthase subunit I is involved in the production of ATP from ADP in the presence of a proton gradient across the membrane

Date:

2019-09-18