Protein Family Models

Date:

2024-09-13

Ths presumed domain is found in the CshA protein from Streptococcus gordonii. The domain is named after the sequence found in CshA in the conserved C-terminal region. The conserved negatively charged residues suggests that this domain may bind to calcium ions. This domain is part of the non-repetitive region NR3 [1]. [1]. 27920201. The Streptococcus gordonii Adhesin CshA Protein Binds Host. Fibronectin via a Catch-Clamp Mechanism.. Back CR, Sztukowska MN, Till M, Lamont RJ, Jenkinson HF, Nobbs. AH, Race PR;. J Biol Chem. 2017;292:1538-1549. (from Pfam)

Date:

2024-08-14

This domain is found on the C-terminal of large number of uncharacterized proteins with broad phylogenetic distribution, which includes human gut Bacteroides, g-proteobacteria (Vibrio and Shewanella) and also spirochetes from Leptospira genus. Solved structure of Bacteroides ovatus protein BACOVA_00967 shows a large beta barrel with an immunoglobulin-like fold and significant structural similarity to collagen-binding domain of adhesin from S. aureus (1amx), but with several additional long loops and secondary structure elements. Function of this domain is unknown. (from Pfam)

Date:

2024-08-14

This domain is abundant in the Leptospira, in Bacteroides, and in Vibrio (three widely separated lineages). Most members have plausible lipoprotein signal peptides, including lipoprotein LruC from Leptospira interrogans and BACOVA_00967, from Bacteroides ovatus, with a solved crystal structure. Note that the C-terminal region of Pfam model PF13448 (length 83) matches the N-terminal region of some members of this domain (length 243).

Date:

2019-09-10

LruC domain-containing protein with a DUF4842 domain

Date:

2021-02-02