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SMODS-associating 2TM, beta-strand rich effector domain
Predicted sensor/effector coupled domain which occurs in conserved genome contexts with the SMODS nucleotide synthetase. In addition to the predicted pore-forming 2TM region, the domain contains seven predicted beta-strands, suggestive of a lipocalin-like beta-barrel structure which could act as the sensor which activates the pore-forming effector response [1]. [1]. 26590262. Comparative genomic analyses reveal a vast, novel network of. nucleotide-centric systems in biological conflicts, immunity and. signaling.. Burroughs AM, Zhang D, Schaffer DE, Iyer LM, Aravind L;. Nucleic Acids Res. 2015;43:10633-10654. (from Pfam)
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