Protein Family Models

Members of this family include both regulatory proteins such as Spx or MgsR and the arsenate reductase ArsC. Some ArsC proteins are selenoproteins.

Date:

2024-08-14

arsenate reductase (ArsC) family protein similar to Synechocystis sp. arsenate reductases ArsI1 and ArsI2, which are glutaredoxin-dependent enzymes that catalyze the reduction of arsenate [As(V)] to arsenite [As(III)]

Date:

2023-02-22

This HMM describes a distinct clade, including ArsC itself, of the broader ArsC family described by Pfam PF03960. This clade is almost completely restricted to the Proteobacteria. An anion-translocating ATPase has been identified as the product of the arsenical resistance operon of resistance plasmid R773. When expressed in Escherichia coli this ATP-driven oxyanion pump catalyses extrusion of the oxyanions arsenite, antimonite and arsenate. The pump is composed of two polypeptides, the products of the arsA and arsB genes. The pump alone produces resistance to arsenite and antimonite. This protein, ArsC, catalyzes the reduction of arsenate to arsenite, and thus extends resistance to include arsenate. Some ArsC proteins are selenoproteins.

Gene:

arsC

Date:

2024-02-27