Protein Family Models

This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyse the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars [1]. Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which exhibits type I phosphodiesterases activity [4]. The alignment encompasses the active site [3,4]. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum [2]. [1]. 9344668. Molecular cloning and chromosomal localization of PD-Ibeta. (PDNP3), a new member of the human phosphodiesterase I genes.. Jin-Hua P, Goding JW, Nakamura H, Sano K;. Genomics 1997;45:412-415.. [2]. 8617788. Cloning and expression of the unique Ca2+-ATPase from. Flavobacterium odoratum.. Peiffer WE, Desrosiers MG, Menick DR;. J Biol Chem 1996;271:5095-5100.. [3]. 7730366. Affinity purification and cDNA cloning of rat neural. differentiation and tumor cell surface antigen gp130RB13-6. reveals relationship to human and murine PC-1.. Deissler H, Lottspeich F, Rajewsky MF;. J Biol Chem 1995;270:9849-9855.. [4]. 7982964. cDNA cloning of the human tumor motility-stimulating protein,. autotaxin, reveals a homology with phosphodiesterases.. Murata J, Lee HY, Clair T, Krutzsch HC, Arestad AA, Sobel ME,. Liotta LA, Stracke ML;. J Biol Chem 1994;269:30479-30484. (from Pfam)

Date:

2024-08-14

alkaline phosphatase family protein catalyzes the hydrolysis of phosphate monoesters or diesters; similar to Saccharomyces cerevisiae ectonucleotide pyrophosphatase/phosphodiesterase 2, which mediates extracellular nucleotide derived phosphate hydrolysis along with NPP1 and PHO5

Date:

2017-12-26