Protein Family Models for Protein (Select 1253028337) - Protein Family Models

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Select item 4233831.

integrase core domain-containing protein

GO Terms:

Biological Process:: DNA integration (GO:0015074)

Date:: 2024-08-14

Family Accession:: NF025063.5
Method:: HMM

Select item 4221492.

IS3 family transposase

This domain contains a predicted helix-turn-helix suggesting a DNA-binding function. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF024673.5
Method:: HMM

Select item 4115603.

transposase

Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family. [1]. 9180700. Genetic organization and transposition properties of IS511.. D. A. Mullin, D. L. Zies, A. H. Mullin, N. Caballera & B. Ely;. Mol Gen Genet 1997;254:456-463.. [2]. 8973350. The use of an improved transposon mutagenesis system for DNA. sequencing leads to the characterization of a new insertion. sequence of Streptomyces lividans 66.. J. Fischer, H. Maier, P. Viell & J. Altenbuchner;. Gene 1996;180:81-89.. [3]. 8917074. Identification and nucleotide sequence of Rhizobium meliloti. insertion sequence ISRm6, a small transposable element that. belongs to the IS3 family.. S. Zekri & N. Toro;. Gene 1996;175:43-48. (from Pfam)

GO Terms:

Molecular Function:: DNA binding (GO:0003677)

Molecular Function:: transposase activity (GO:0004803)

Biological Process:: DNA transposition (GO:0006313)

Date:: 2024-08-14

Family Accession:: NF013677.5
Method:: HMM

Select item 4111094.

DDE-type integrase/transposase/recombinase

Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain Pfam:PF02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain Pfam:PF00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site [1]. [1]. 7801124. Crystal structure of the catalytic domain of HIV-1 integrase:. similarity to other polynucleotidyl transferases [see comments]. Dyda F, Hickman AB, Jenkins TM, Engelman A, Craigie R, Davies. DR;. Science 1994;266:1981-1986. (from Pfam)

GO Terms:

Biological Process:: DNA integration (GO:0015074)

Date:: 2024-08-14

Family Accession:: NF012870.5
Method:: HMM

Select item 4009905.