Protein Family Models

This domain represents the N-terminal glycosyltransferase from a set of toxins found in some bacteria. This domain in TcdB glycosylates the host RhoA protein. [1]. 16054646. Structural basis for the function of Clostridium difficile toxin. B.. Reinert DJ, Jank T, Aktories K, Schulz GE;. J Mol Biol. 2005;351:973-981. (from Pfam)

Date:

2024-08-14

This family consists of several capsular polysaccharide proteins. Capsular polysaccharide (CPS) is a major virulence factor in Streptococcus pneumoniae [1]. [1]. 11179285. Molecular characterization of Streptococcus pneumoniae type 4,. 6B, 8, and 18C capsular polysaccharide gene clusters.. Jiang SM, Wang L, Reeves PR;. Infect Immun 2001;69:1244-1255.. [2]. 9838125. Molecular structure of the gene cluster responsible for the. synthesis of the polysaccharide capsule of Streptococcus. pneumoniae type 33F.. Llull D, Lopez R, Garcia E, Munoz R;. Biochim Biophys Acta 1998;1443:217-224.. [3]. 10688204. The genome sequence of the food-borne pathogen Campylobacter. jejuni reveals hypervariable sequences.. Parkhill J, Wren BW, Mungall K, Ketley JM, Churcher C, Basham D,. Chillingworth T, Davies RM, Feltwell T, Holroyd S, Jagels K,. Karlyshev AV, Moule S, Pallen MJ, Penn CW, Quail MA, Rajandream. MA, Rutherford KM, van Vliet AH, Whitehead S, Barrell BG;. Nature 2000;403:665-668.. [4]. 7752885. Region II of the Haemophilus influenzae type be capsulation. locus is involved in serotype-specific polysaccharide synthesis.. Van Eldere J, Brophy L, Loynds B, Celis P, Hancock I, Carman S,. Kroll JS, Moxon ER;. Mol Microbiol 1995;15:107-118.. [5]. 10094675. acs1 of Haemophilus influenzae type a capsulation locus region. II encodes a bifunctional ribulose 5-phosphate reductase-. CDP-ribitol pyrophosphorylase.. Follens A, Veiga-da-Cunha M, Merckx R, van Schaftingen E, van. Eldere J;. J Bacteriol 1999;181:2001-2007. (from Pfam)

Date:

2024-08-14

The DXD motif is a short conserved motif found in many families of glycosyltransferases, which add a range of different sugars to other sugars, phosphates and proteins. DXD-containing glycosyltransferases all use nucleoside diphosphate sugars as donors and require divalent cations, usually manganese. The DXD motif is expected to play a carbohydrate binding role in sugar-nucleoside diphosphate and manganese dependent glycosyltransferases [1]. [1]. 9653120. Activity of the yeast MNN1 alpha-1,3-mannosyltransferase. requires a motif conserved in many other families of. glycosyltransferases.. Wiggins CA, Munro S;. Proc Natl Acad Sci U S A 1998;95:7945-7950. (from Pfam)

Date:

2024-08-14

glycosyltransferase family 32 protein similar to initiation-specific alpha-1,6-mannosyltransferase that is involved in outer chain elongation of asparagine-linked oligosaccharides of the type Man(9)GlcNAc(2)

Date:

2024-06-26