Protein Family Models

A predicted RNase toxin found in bacterial polymorphic toxin systems. The toxin possesses an all-alpha helical fold and conserved lysine and cysteine residues, and GNxxD and WxCxH motifs. In bacterial polymorphic toxin systems, the toxin is exported by the type 2 or type 6 secretion system [1]. [1]. 22731697. Polymorphic toxin systems: comprehensive characterization of. trafficking modes, processing, mechanisms of action, immunity. and ecology using comparative genomics.. Zhang D, de Souza RF, Anantharaman V, Iyer LM, Aravind L;. Biol Direct. 2012;7:18. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14

protein containing domains PAAR_like, RHS_core, and Ntox34

Date:

2017-03-02

This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (PF01839) class, and an RHS repeat (PF05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.

Date:

2023-02-23