Protein Family Models for Protein (Select 1445118078) - Protein Family Models

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Select item 4255681.

topoisomerase C-terminal repeat-containing protein

Date:: 2024-08-14

Family Accession:: NF024738.5
Method:: HMM

Select item 4135442.

DNA topoisomerase

This HMM identifies a region shared by DNA topoisomerases of different types, including ATP-independent (type I) topoisomerases such as TopA and TopB, and ATP-dependent reverse gyrases.

GO Terms:

Molecular Function:: DNA binding (GO:0003677)

Molecular Function:: DNA topoisomerase activity (GO:0003916)

Biological Process:: DNA topological change (GO:0006265)

Date:: 2024-08-14

Family Accession:: NF013311.5
Method:: HMM

Select item 4124483.

toprim domain-containing protein

This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins [1]. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity [1]. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesises the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division [2]. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases [4]. Type II DNA topoisomerases catalyse the relaxation of DNA supercoiling by causing transient double strand breaks. [1]. 9722641. Toprim--a conserved catalytic domain in type IA and II. topoisomerases, DnaG-type primases, OLD family nucleases and. RecR proteins.. Aravind L, Leipe DD, Koonin EV;. Nucleic Acids Res 1998;26:4205-4213.. [2]. 9224947. Cloning and analysis of the dnaG gene encoding Pseudomonas. putida DNA primase.. Szafranski P, Smith CL, Cantor CR;. Biochim Biophys Acta 1997;1352:243-248.. [3]. 8294018. The Haemophilus influenzae dnaG sequence and conserved bacterial. primase motifs.. Versalovic J, Lupski JR;. Gene 1993;136:281-286.. [4]. 9121560. An atypical topoisomerase II from Archaea with implications for. meiotic recombination.. Bergerat A, de Massy B, Gadelle D, Varoutas PC, Nicolas A,. Forterre P;. Nature 1997;386:414-417. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF013878.5
Method:: HMM

Select item 4029894.

new record, indexing in progress

Family Accession:

Select item 3901265.

new record, indexing in progress

Family Accession:

Select item 3890326.

new record, indexing in progress

Family Accession:

Select item 3570677.

new record, indexing in progress

Family Accession:

Select item 3483848.

new record, indexing in progress

Family Accession:

Select item 3475939.

new record, indexing in progress

Family Accession:

Select item 32682510.

new record, indexing in progress

Family Accession:

Select item 31732311.

new record, indexing in progress

Family Accession:

Select item 31625612.

new record, indexing in progress

Family Accession:

Select item 12808413.

type IA DNA topoisomerase

type IA DNA topoisomerase resolves single strand DNA recombination and replication intermediates

Date:: 2022-08-17

Family Accession:: 13449637
Method:: Sparcle

Select item 7128014.

new record, indexing in progress

Family Accession:

Select item 7070315.

new record, indexing in progress

Family Accession:

Select item 3177416.

DNA topoisomerase 3

GO Terms:

Molecular Function:: DNA binding (GO:0003677)

Molecular Function:: DNA topoisomerase activity (GO:0003916)

Biological Process:: DNA topological change (GO:0006265)

Date:: 2021-08-24

Family Accession:: NF005829.0
Method:: HMM

Select item 3137217.

new record, indexing in progress

Family Accession:

Select item 3032918.

new record, indexing in progress

Family Accession:

Select item 2587319.

new record, indexing in progress

Family Accession:

Select item 2513220.

DNA topoisomerase III

This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent.

Gene:: topB

GO Terms:

Molecular Function:: DNA binding (GO:0003677)

Molecular Function:: DNA topoisomerase type I (single strand cut, ATP-independent) activity (GO:0003917)

Biological Process:: DNA topological change (GO:0006265)

Date:: 2021-04-27

Family Accession:: TIGR01056.1
Method:: HMM

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