Protein Family Models for Protein (Select 1589799654) - Protein Family Models

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Items: 6

Select item 4128561.

This enzyme EC:4.1.2.25 catalyses the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin in the biosynthetic pathway of tetrahydrofolate. [1]. 9651328. Biosynthesis of pteridines in Escherichia coli. Structural and. mechanistic similarity of dihydroneopterin-triphosphate. epimerase and dihydroneopterin aldolase.. Haussmann C, Rohdich F, Schmidt E, Bacher A, Richter G;. J Biol Chem 1998;273:17418-17424. (from Pfam)

GO Terms:

Molecular Function:: dihydroneopterin aldolase activity (GO:0004150)

Biological Process:: folic acid-containing compound metabolic process (GO:0006760)

Date:: 2024-08-14

Family Accession:: NF014233.5
Method:: HMM

Select item 3903802.

new record, indexing in progress

Family Accession:

Select item 3482183.

new record, indexing in progress

Family Accession:

Select item 270614.

dihydroneopterin aldolase

dihydroneopterin aldolase (DHNA) catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and may also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin

Date:: 2018-02-07

Family Accession:: 10015677
Method:: Sparcle

Select item 199895.

dihydroneopterin aldolase

This model describes a bacterial dihydroneopterin aldolase, shown to form homo-octamers in E. coli. The equivalent activity is catalyzed by domains of larger folate biosynthesis proteins in other systems. The closely related parologous enzyme in E. coli, dihydroneopterin triphosphate epimerase, which is also homo-octameric, and dihydroneopterin aldolase domains of larger proteins, score below the trusted cutoff but may score well above the noise cutoff.

Gene:: folB

GO Terms:

Molecular Function:: dihydroneopterin aldolase activity (GO:0004150)

Biological Process:: folic acid-containing compound metabolic process (GO:0006760)

Date:: 2021-04-27

Family Accession:: TIGR00525.1
Method:: HMM

Select item 193776.

FolB domain-containing protein

Two paralogous genes of E. coli, folB (dihydroneopterin aldolase) and folX (d-erythro-7,8-dihydroneopterin triphosphate epimerase) are homologous to each other and homo-octameric. In Pneumocystis carinii, a multifunctional enzyme of folate synthesis has an N-terminal region active as dihydroneopterin aldolase. This region consists of two tandem sequences each homologous to folB and forms tetramers.

GO Terms: