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SNO glutamine amidotransferase family
This family and its amidotransferase domain was first described in [1]. It is predicted that members of this family are involved in the pyridoxine biosynthetic pathway, based on the proximity and co-regulation of the corresponding genes and physical interaction between the members of Pfam:PF01174 and Pfam:PF01680 [2]. [1]. 9159529. Sequence analysis of an exceptionally conserved operon suggests. enzymes for a new link between histidine and purine. biosynthesis.. Galperin MY, Koonin EV;. Mol Microbiol 1997;24:443-445.. [2]. 9791124. The highly conserved, coregulated SNO and SNZ gene families in. Saccharomyces cerevisiae respond to nutrient limitation.. Padilla PA, Fuge EK, Crawford ME, Errett A, Werner-Washburne M;. J Bacteriol 1998;180:5718-5726. (from Pfam)
Glutamine amidotransferase class-I
imidazole glycerol phosphate synthase subunit HisH
This HMM represents HisH, the glutamine amidotransferase subunit (or domain, in eukaryotic systems) of imidazole glycerol phosphate synthase. IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate during histidine biosynthesis.
type 1 glutamine amidotransferase subunit (HisH) of imidazole glycerol phosphate synthase
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