Protein Family Models

This domain is found at the C-terminus of a variety of large catalase enzymes from bacteria. Structurally it is related to class I glutamine amidotransferase domains. The precise molecular function of this domain is uncertain. [1]. 10488114. Mutants that alter the covalent structure of catalase. hydroperoxidase II from Escherichia coli.. Mate MJ, Sevinc MS, Hu B, Bujons J, Bravo J, Switala J, Ens W,. Loewen PC, Fita I;. J Biol Chem. 1999;274:27717-27725.. [2]. 11455600. Substrate flow in catalases deduced from the crystal structures. of active site variants of HPII from Escherichia coli.. Melik-Adamyan W, Bravo J, Carpena X, Switala J, Mate MJ, Fita I,. Loewen PC;. Proteins. 2001;44:270-281.. [3]. 7663946. Crystal structure of catalase HPII from Escherichia coli.. Bravo J, Verdaguer N, Tormo J, Betzel C, Switala J, Loewen PC,. Fita I;. Structure. 1995;3:491-502.. [4]. 12777389. An electrical potential in the access channel of catalases. enhances catalysis.. Chelikani P, Carpena X, Fita I, Loewen PC;. J Biol Chem. 2003;278:31290-31296.. [5]. 21332158. Modulation of heme orientation and binding by a single residue. in catalase HPII of Escherichia coli.. Jha V, Louis S, Chelikani P, Carpena X, Donald LJ, Fita I,. Loewen PC;. Biochemistry. 2011;50:2101-2110.. [6]. 22172685. Mutation of Phe413 to Tyr in catalase KatE from Escherichia coli. leads to side chain damage and main chain cleavage.. Jha V, Donald LJ, Loewen PC;. Arch Biochem Biophys. 2012;525:207-214.. [7]. 24223139. Post-transcriptional regulator Hfq binds catalase HPII: crystal. structure of the complex.. Yonekura K, Watanabe M, Kageyama Y, Hirata K, Yamamoto M,. Ma. TRUNCATED at 1650 bytes (from Pfam)

Date:

2024-08-14

This family represents a small conserved region within catalase enzymes (EC:1.11.1.6). All members also contain the Catalase family, Pfam:PF00199 domain. Catalase decomposes hydrogen peroxide into water and oxygen, serving to protect cells from its toxic effects [1]. This domain carries the immune-responsive amphipathic octa-peptide that is recognised by T cells [2]. [1]. 11351128. Mitochondrial catalase and oxidative injury.. Bai J, Cederbaum AI;. Biol Signals Recept 2001;10:189-199.. [2]. 15585332. Do Th1 or Th2 sequence motifs exist in proteins? Identification. of amphipatic immunomodulatory domains in Helicobacter pylori. catalase.. Guy B, Krell T, Sanchez V, Kennel A, Manin C, Sodoyer R;. Immunol Lett. 2005;96:261-275. (from Pfam)

Date:

2024-08-14

The family includes the protease PfpI Swiss:Q51732 [1]. This domain is also found in transcriptional regulators such as Swiss:Q9RJG8. [1]. 8626329. Sequence, expression in Escherichia coli, and analysis of the. gene encoding a novel intracellular protease (PfpI) from the. hyperthermophilic archaeon Pyrococcus furiosus.. Halio SB, Blumentals II, Short SA, Merrill BM, Kelly RM;. J Bacteriol 1996;178:2605-2612.. [2]. 15784968. AdpA, a central transcriptional regulator in the A-factor. regulatory cascade that leads to morphological development and. secondary metabolism in Streptomyces griseus.. Ohnishi Y, Yamazaki H, Kato JY, Tomono A, Horinouchi S;. Biosci Biotechnol Biochem. 2005;69:431-439. (from Pfam)

Date:

2024-08-14

Date:

2024-08-14