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flotillin domain-containing protein
Flotillin is a family of lipid-membrane-associated proteins found in bacteria, archaea and eukaryotes. The family is found in association with Pfam:PF01145, another integral membrane-associated domain. Flotillins in vertebrates are associated with sphingolipids and cholesterol-enriched membrane microdomains known as lipid-rafts. These rafts along with other membrane components are important in cell-signalling. Flotillins in other organisms have roles in viral pathogenesis, endocytosis, and membrane shaping. [1]. 20018678. Plant flotillins are required for infection by nitrogen-fixing. bacteria.. Haney CH, Long SR;. Proc Natl Acad Sci U S A. 2010;107:478-483.. [2]. 22194304. The roles of flotillin microdomains--endocytosis and beyond.. Otto GP, Nichols BJ;. J Cell Sci. 2011;124:3933-3940.. [3]. 22215737. Flotillin-1 (Reggie-2) contributes to Chlamydia pneumoniae. growth and is associated with bacterial inclusion.. Korhonen JT, Puolakkainen M, Haivala R, Penttila T, Haveri A,. Markkula E, Lahesmaa R;. Infect Immun. 2012;80:1072-1078.. [4]. 22882210. The biofilm formation defect of a Bacillus subtilis. flotillin-defective mutant involves the protease FtsH.. Yepes A, Schneider J, Mielich B, Koch G, Garcia-Betancur JC,. Ramamurthi KS, Vlamakis H, Lopez D;. Mol Microbiol. 2012;86:457-471. (from Pfam)
SPFH domain-containing protein
This family has been called SPFH [1], Band 7 or PHB domain. Recent phylogenetic analysis has shown this domain to be a slipin or Stomatin-like integral membrane domain conserved from protozoa to mammals. [1]. 10542406. The SPFH domain: implicated in regulating targeted protein. turnover in stomatins and other membrane-associated proteins.. Tavernarakis N, Driscoll M, Kyrpides NC;. Trends Biochem Sci 1999;24:425-427.. [2]. 18267007. Slipins: ancient origin, duplication and diversification of the. stomatin protein family.. Green JB, Young JP;. BMC Evol Biol. 2008;8:44. (from Pfam)
flotillin lipid rafts scaffold protein FloT
flotillin family protein
flotillin family protein may act as a scaffolding protein within caveolar membranes, functionally participating in the formation of caveolae or caveolae-like vesicles
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