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M24 family metallopeptidase
This family contains metallopeptidases. It also contains non-peptidase homologues such as the N terminal domain of Spt16 which is a histone H3-H4 binding module [3]. The structure of a representative of this family.. [1]. 8471602. Structure of the cobalt-dependent methionine aminopeptidase from. Escherichia coli: a new type of proteolytic enzyme.. Roderick SL, Matthews BW. Biochemistry 1993;32:3907-3912.. -!- Members of this family are metallopeptidases. They belong. to family M24 in the classification of Rawlings and Barrett.. [2]. 7674922. Evolutionary families of metallopeptidases.. Rawlings ND, Barrett AJ;. Meth Enzymol 1995;248:183-228.. [3]. 18579787. The FACT Spt16 "peptidase" domain is a histone H3-H4 binding. module.. Stuwe T, Hothorn M, Lejeune E, Rybin V, Bortfeld M, Scheffzek K,. Ladurner AG;. Proc Natl Acad Sci U S A. 2008;105:8884-8889. (from Pfam)
M24 family metallopeptidase cleaves amido-, imido- or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes
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