Protein Family Models for Protein (Select 1779109092) - Protein Family Models

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Links from Protein

Items: 6

Select item 4226771.

Glutathione S-transferase, N-terminal domain

This family is closely related to Pfam:PF02798. (from Pfam)

GO Terms:

Molecular Function:: protein binding (GO:0005515)

Biological Process:: glutathione metabolic process (GO:0006749)

Date:: 2024-08-14

Family Accession:: NF024801.5
Method:: HMM

Select item 4114402.

glutaredoxin domain-containing protein

GO Terms:

Molecular Function:: protein-disulfide reductase activity (GO:0015035)

Date:: 2024-08-14

Family Accession:: NF012675.5
Method:: HMM

Select item 3883113.

new record, indexing in progress

Family Accession:

Select item 3567764.

new record, indexing in progress

Family Accession:

Select item 3481165.

new record, indexing in progress

Family Accession:

Select item 1422876.

glutaredoxin 3

Glutaredoxins are thioltransferases (disulfide reductases) which utilize glutathione and NADPH as cofactors. Oxidized glutathione is regenerated by glutathione reductase. Together these components compose the glutathione system [1]. Glutaredoxins utilize the CXXC motif common to thioredoxins and are involved in multiple cellular processes including protection from redox stress, reduction of critical enzymes such as ribonucleotide reductase and the generation of reduced sulfur for iron sulfur cluster formation. Glutaredoxins are capable of reduction of mixed disulfides of glutathione as well as the formation of glutathione mixed disulfides. This family of glutaredoxins includes the E. coli protein GrxC (Grx3) which appears to have a secondary role in reducing ribonucleotide reductase (in the absence of GrxA) possibly indicating a role in the reduction of other protein disulfides [2].