Protein Family Models

Date:

2024-08-14

This entry represents a wide variety of bacterial Ig domains. [1]. 21606337. Structure of a bacterial cell surface decaheme electron conduit.. Clarke TA, Edwards MJ, Gates AJ, Hall A, White GF, Bradley J,. Reardon CL, Shi L, Beliaev AS, Marshall MJ, Wang Z, Watmough NJ,. Fredrickson JK, Zachara JM, Butt JN, Richardson DJ;. Proc Natl Acad Sci U S A. 2011;108:9384-9389. (from Pfam)

Date:

2024-08-14

This entry contains numerous bacterial cadherin-like domains found in extracelullar proteins. (from Pfam)

Date:

2024-08-14

This domain family is found in bacteria and eukaryotes, and is approximately 160 amino acids in length. There are two completely conserved residues (C and G) that may be functionally important. (from Pfam)

Date:

2024-08-14

This alignment represents the conserved core region of ~90 residue repeat found in several haemagglutinins and other cell surface proteins. Sequence similarities to (Pfam:PF02494) and (Pfam:PF00801) suggest an Ig-like fold (personal obs:C. Yeats). So this family may be similar in function to the (Pfam:PF02639) and (Pfam:PF02638) domains. This domain is also found in the WisP family of proteins of Tropheryma whipplei ([1]). [1]. 12606174. Sequencing and analysis of the genome of the Whipple's disease. bacterium Tropheryma whipplei.. Bentley SD, Maiwald M, Murphy LD, Pallen MJ, Yeats CA, Dover LG,. Norbertczak HT, Besra GS, Quail MA, Harris DE, von Herbay A,. Goble A, Rutter S, Squares R, Squares S, Barrell BG, Parkhill J,. Relman DA;. Lancet 2003;361:637-644. (from Pfam)

Date:

2024-08-14

This domain of about 100 residues was found originally in multiple (up to 35) copies in long proteins from several species of Vibrio, Colwellia, Bradyrhizobium, and Shewanella (hence the name VCBS) and in smaller copy numbers in proteins from several other bacteria. The large protein size and repeat copy numbers, species distribution, and suggested activities of several member proteins suggests a role for this domain in adhesion. This HMM for a repeated domain overlaps substantially (shifted by half its length) with newer Pfam model PF17803 (bacterial cadherin-like domain).

Date:

2020-10-24

This 95-amino acid repeat occurs in tandem in proteins that may be several thousand amino acids long.

Date:

2020-10-26