Protein Family Models for Protein (Select 1832478381) - Protein Family Models

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Items: 5

Select item 4118671.

TatD family hydrolase

This family of proteins are related to a large superfamily of metalloenzymes [1]. TatD, a member of this family has been shown experimentally to be a DNase enzyme. [1]. 9144792. An evolutionary treasure: unification of a broad set of. amidohydrolases related to urease.. Holm L, Sander C;. Proteins 1997;28:72-82.. [2]. 10747959. TatD is a cytoplasmic protein with DNase activity. No. requirement for TatD family proteins in sec-independent protein. export.. Wexler M, Sargent F, Jack RL, Stanley NR, Bogsch EG, Robinson C,. Berks BC, Palmer T;. J Biol Chem 2000;275:16717-16722. (from Pfam)

GO Terms:

Molecular Function:: hydrolase activity, acting on ester bonds (GO:0016788)

Date:: 2024-08-14

Family Accession:: NF013213.5
Method:: HMM

Select item 3901162.

new record, indexing in progress

Family Accession:

Select item 3475873.

new record, indexing in progress

Family Accession:

Select item 217654.

TatD family hydrolase

TatD family hydrolase is a metal-dependent hydrolase similar to Homo sapiens deoxyribonuclease TATDN3

Date:: 2024-04-17

Family Accession:: 10000566
Method:: Sparcle

Select item 166695.

YchF/TatD family DNA exonuclease

PSI-BLAST, starting with a urease alpha subunit, finds a large superfamily of proteins, including a number of different enzymes that act as hydrolases at C-N bonds other than peptide bonds (EC 3.5.-.-), many uncharacterized proteins, and the members of this family. Several genomes have multiple paralogs related to this family. However, a set of 17 proteins can be found, one each from 17 of the first 20 genomes, such that each member forms a bidirectional best hit across genomes with all other members of the set. This core set (and one other near-perfect member), but not the other paralogs, form the seed for this model. Additionally, members of the seed alignment and all trusted hits, but not all paralogs, have a conserved motif DxHxH near the amino end. The member from E. coli was recently shown to have DNase activity.

GO Terms: