Protein Family Models for Protein (Select 1862330099) - Protein Family Models

Select item 4232371.

Phage integrase, N-terminal SAM-like domain

This domain is found in a variety of phage integrase proteins. (from Pfam)

GO Terms:

Molecular Function:: DNA binding (GO:0003677)

Biological Process:: DNA integration (GO:0015074)

Date:: 2024-08-14

Family Accession:: NF026010.5
Method:: HMM

Select item 4209952.

phage integrase SAM-like domain-containing protein

A family of uncharacterised proteins found by clustering human gut metagenomic sequences [1]. This family appears related to the N-terminal domain of phage integrases. [1]. 20532204. Expansion of the protein repertoire in newly explored. environments: human gut microbiome specific protein families. Ellrott K, Jaroszewski L, Weizhong L, Wooley J, Godzik, A. PLoS Computational Biology, 2010 (from Pfam)

Date:: 2024-08-14

Family Accession:: NF024502.5
Method:: HMM

Select item 4113303.

tyrosine-type recombinase/integrase

Members of this family cleave DNA substrates by a series of staggered cuts, during which the protein becomes covalently linked to the DNA through a catalytic tyrosine residue at the carboxy end of the alignment. The catalytic site residues in CRE recombinase (Swiss:P06956) are Arg-173, His-289, Arg-292 and Tyr-324. [1]. 9082984. Flexibility in DNA recombination: structure of the lambda. integrase catalytic core.. Kwon HJ, Tirumalai R, Landy A, Ellenberger T;. Science 1997;276:126-131.. [2]. 9288963. Structure of Cre recombinase complexed with DNA in a. site-specific recombination synapse.. Guo F, Gopaul DN, van Duyne GD;. Nature 1997;389:40-46. (from Pfam)

GO Terms:

Molecular Function:: DNA binding (GO:0003677)

Biological Process:: DNA recombination (GO:0006310)

Biological Process:: DNA integration (GO:0015074)

Date:: 2024-08-14

Family Accession:: NF012798.5
Method:: HMM

Select item 4013994.