SelO and its homologues are widespread among most eukaryotic taxa, and are also common in many major bacterial taxa. SelO is a conserved pseudokinase that transfers AMP from ATP to Ser, Thr, and Tyr residues on protein substrates (AMPylation). It contains a protein kinase fold with ATP flipped in the active site [1]. In eukaryotes, it is a mitochondrial protein that may be involved in redox biology [2]. [1]. 30270044. Protein AMPylation by an Evolutionarily Conserved Pseudokinase.. Sreelatha A, Yee SS, Lopez VA, Park BC, Kinch LN, Pilch S,. Servage KA, Zhang J, Jiou J, Karasiewicz-Urbanska M, Lobocka M,. Grishin NV, Orth K, Kucharczyk R, Pawlowski K, Tomchick DR,. Tagliabracci VS;. Cell. 2018;175:809-821.. [2]. 24751718. Characterization of mammalian selenoprotein o: a redox-active. mitochondrial protein.. Han SJ, Lee BC, Yim SH, Gladyshev VN, Lee SR;. PLoS One. 2014;9:e95518. (from Pfam)
- Date:
- 2024-07-08