Protein Family Models

This family includes Succinylglutamate desuccinylase EC:3.1.-.- that catalyses the fifth and last step in arginine catabolism by the arginine succinyltransferase pathway. The family also include aspartoacylase EC:3.5.1.15 which cleaves acylaspartate into a fatty acid and aspartate. Mutations in Swiss:P45381 lead to Canavan disease disease [1]. This family is probably structurally related to Pfam:PF00246 (Bateman A pers. obs.). [1]. 8252036. Cloning of the human aspartoacylase cDNA and a common missense. mutation in Canavan disease.. Kaul R, Gao GP, Balamurugan K, Matalon R;. Nat Genet 1993;5:118-123. (from Pfam)

Date:

2024-08-14

succinylglutamate desuccinylase catalyzes the formation of succinate and L-glutamate from N-succinyl-L-glutamate in the fifth and final reaction of the ammonia-producing arginine catabolic pathway, L-arginine degradation II (AST pathway)

Date:

2023-03-13

Members of this protein family are succinylglutamate desuccinylase, the fifth and final enzyme of the arginine succinyltransferase (AST) pathway for arginine catabolism. This model excludes the related protein aspartoacylase.

Gene:

astE

Date:

2024-06-04

Catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism

Date:

2020-10-26