Protein Family Models for Protein (Select 1896435316) - Protein Family Models

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Items: 8

Select item 4164181.

This family represents five transmembrane helices that are normally found flanking (five either side) a pair of Pfam:PF02080 domains. This suggests that the paired regions form a ten helical structure, probably forming the pore, whereas the Pfam:PF02080) binds a ligand for export or regulation of the pore. Swiss:Q8L3K8 is described as a aspartate-alanine antiporter ([1]). In conjunction with Swiss:Q8L3K9 it forms a 'proton motive metabolic cycle catalysed by an aspartate-alanine exchange'. The general conservation of domain architecture in this family suggests that they are functional orthologues. [1]. 12003930. Plasmid-encoded asp operon confers a proton motive metabolic. cycle catalyzed by an aspartate-alanine exchange reaction.. Abe K, Ohnishi F, Yagi K, Nakajima T, Higuchi T, Sano M, Machida. M, Sarker RI, Maloney PC;. J Bacteriol 2002;184:2906-2913. (from Pfam)

Date:: 2024-08-14

Family Accession:: NF018530.5
Method:: HMM

Select item 4134202.

TrkA C-terminal domain-containing protein

This domain is often found next to the Pfam:PF02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand [1]. The domain is predicted to adopt an all beta structure [1]. [1]. 11292341. Regulatory potential, phyletic distribution and evolution of. ancient, intracellular small-molecule-binding domains.. Anantharaman V, Koonin EV, Aravind L;. J Mol Biol 2001;307:1271-1292. (from Pfam)

GO Terms:

Biological Process:: potassium ion transport (GO:0006813)

Molecular Function:: monoatomic cation transmembrane transporter activity (GO:0008324)

Date:: 2024-08-14

Family Accession:: NF014171.5
Method:: HMM

Select item 3950523.

new record, indexing in progress

Family Accession:

Select item 3902504.

new record, indexing in progress

Family Accession:

Select item 3517795.

new record, indexing in progress

Family Accession:

Select item 3482156.

new record, indexing in progress

Family Accession:

Select item 2088537.

aspartate:alanine exchanger family transporter

aspartate:alanine exchanger (AAEx) family transporter similar to transport protein YbjL

Date:: 2022-08-23

Family Accession:: 11459491
Method:: Sparcle

Select item 1427638.

AspT/YidE/YbjL antiporter duplication domain

This model represents a domain that is duplicated the aspartate-alanine antiporter AspT, as well as HI0035 of Haemophilus influenzae, YidE and YbjL of E. coli, and a number of other known or putative transporters. Member proteins may have 0, 1, or 2 copies of TrkA potassium uptake domain PF02080 between the duplications. The domain contains several apparent transmembrane regions and is proposed here to act in transport.